In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes

Archives of Medical Research
T RamirezL A Herrera

Abstract

Albendazole (ABZ) is an antiparasitic drug used for the treatment of several helminthiases. After its oral administration, this compound is metabolized to sulfoxide (SOABZ) and sulfone (SO(2)ABZ), SOABZ being the active metabolite. The antiparasitic activity of ABZ has been associated with its capacity to bind with tubulin, altering microtubule formation. Although some studies indicate that ABZ modified microtubule structure in host cells, data concerning the consequences of this phenomenon in human cells are scant. In this study we evaluated the effects of ABZ and its metabolites on cell proliferation, as well as on the frequency of micronucleated cells in cultured human lymphocytes. ABZ and SOABZ arrested cell proliferation in metaphase and increased the frequency of micronuclei in treated lymphocytes. Contrariwise, SO(2)ABZ, the inactive metabolite, did not produce any significant effect. The formation of micronuclei may ultimately result in aneuploidy induction, an effect that could have severe consequences in humans. However, the doses of ABZ and SOABZ at which these effects were observed are several orders of magnitude higher than those found in the plasma of treated individuals. Because there are other mechanisms by whic...Continue Reading

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Citations

Jul 19, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ulises RodríguezLuis A Herrera
Dec 2, 2008·Mutation Research·Ana María SalazarPatricia Ostrosky-Wegman
Jul 3, 2004·Redox Report : Communications in Free Radical Research·Claudriana LocatelliDanilo Wilhelm-Filho
Mar 3, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sitki OztasHusnu Kursad
Aug 27, 2013·Pharmacology & Therapeutics·Ivan RusynKathryn Z Guyton
Oct 24, 2006·Mutation Research·Tzutzuy RamírezLuis A Herrera
Oct 21, 2016·American Journal of Physiology. Renal Physiology·Eugen WidmeierFriedhelm Hildebrandt
May 23, 2013·Polish Journal of Veterinary Sciences·D TsiboukisM Leotsinidis
Oct 13, 2012·International Journal of Cosmetic Science·K H Son, M Y Heo
Aug 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John JacobSusan Jarvi

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