PMID: 16538046Mar 16, 2006Paper

In vitro effects of arecoline on sperm motility and cyclooxygenase-2 expression

The Journal of Toxicological Sciences
Tze-Kiong ErJau-Nan Lee

Abstract

Semen samples were obtained from 30 volunteers who had never consumed betel quid. Swim-up spermatozoa from the 30 seminal samples of non-betel quid chewers and also non-smokers, usually not exposed to passive smoking, were treated in vitro with arecoline at different concentrations to evaluate the action of these drugs on sperm motility. Highly motile sperms were collected and divided into 5 equal fractions. Four fractions were supplemented with various concentrations of arecoline and one as control. The study was carried out at time 0 and +1, +2, +3 and +4 hr of incubation. Sperm cells were also extracted and blotted with COX-2 antibody after arecoline treatment after 4 hr incubation. The sperm motility parameters, i.e., motility, average path velocity, curvilinear velocity, straight-line velocity and linearity, were significantly decreased after arecoline treatment. In vitro, arecoline induces the COX-2 expression of sperm cells in a dose-dependent manner. This is the first report to demonstrate that arecoline may mediate COX-2 expression in human sperms, resulting in inflammation response. This situation may act on the structure responsible for the flagellar motion and cause the reduction of sperm motility.

References

Oct 27, 1979·Lancet·B G Burton-Bradley
Sep 1, 1975·Fertility and Sterility·J G CollierS L Stanton
Jul 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoS F Hsieh
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·B J DaveS G Adhvaryu
Oct 1, 1988·Molecular and Cellular Biology·M T TippettsH R Herschman
Aug 1, 1970·Fertility and Sterility·M BygdemanB Samuelsson
Jun 1, 1981·Archives of Andrology·L C EllisR J Tesi
Jan 1, 1984·Fertility and Sterility·M J CosentinoA T Cockett
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·X LuD L Simmons
Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoC C Tsai
Apr 1, 1997·Human Reproduction·L GandiniF Dondero
Aug 5, 1998·The American Journal of Physiology·R E StewartJ A DeSimone
Feb 9, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J H JengM C Chang
May 18, 2001·Clinical Oral Investigations·Y C ChangM Y Chou
Oct 1, 1993·European Journal of Cancer. Part B, Oral Oncology·S Thomas, J Kearsley
Dec 6, 2001·Journal of Toxicology and Environmental Health. Part a·M J YangY C Ko
Feb 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Hung TsaiYu-Chao Chang
Mar 24, 2004·Inflammopharmacology·Kristina M Stanfield, K Nasir M Khan
Apr 7, 2004·Journal of Chromatography. a·Stephen CoxGary Ma
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Timothy D Warner, Jane A Mitchell
Jun 3, 2004·Oral Oncology·Binu J JacobMia Hashibe

❮ Previous
Next ❯

Citations

Sep 19, 2012·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Gunjan ShahSagar Vaishampayan
Sep 10, 2014·Journal of Biomedical Science·Tzer-Min KuoYing-Chin Ko
Apr 21, 2012·Journal of Food Science·Jingsong YuanDean Guo
Oct 14, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shao-Tung LiuYung-Fu Chang
Aug 1, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yung-Fu ChangChao-Neng Tseng
Feb 24, 2011·Toxicology and Industrial Health·A KumariSunil Kumar
Jun 20, 2020·Cell Proliferation·Wei-Dong LiMinghui Zhao
Jul 12, 2011·Toxicology and Applied Pharmacology·Indraneel SahaUrmi Chatterji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.