In vitro effects of atorvastatin on lipopolysaccharide-induced gene expression in endometriotic stromal cells

Fertility and Sterility
Indu SharmaLakhbir Kaur Dhaliwal

Abstract

To investigate the in vitro effects of atorvastatin on lipopolysaccharide (LPS)-induced gene expression in endometrial-endometriotic stromal cells. In vitro experimental study using flow cytometry, ELISA, semiquantitative reverse transcriptase polymerase chain reaction, and Western blot. Postgraduate Institute of Medical Education and Research. Twenty-five women undergoing laparoscopy (n = 10) and laparotomy (n = 15). Endometriotic cyst wall (group I) and endometrial biopsy (group II) collection. The endometrial-endometriotic stromal cells were isolated from ectopic (group I) and eutopic (group II) endometrium by established methods, cultured, and stimulated with LPS (1 μg/mL), followed by atorvastatin treatment in a time- and dose-dependent manner to investigate the effects of LPS on proliferation (Ki-67) and expression of cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), receptor for advanced glycation end products (RAGE), extracellular newly identified RAGE binding protein (EN-RAGE), peroxisome proliferator activated receptor-γ (PPAR-γ), and liver X receptor-α (LXR-α) genes in endometrial-endometriotic stromal cells and on levels of insulin-like growth factor binding protein-1 (IGFBP-1) and 17β-E(2) in end...Continue Reading

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Citations

Apr 12, 2012·Biology of Reproduction·Anna SokalskaAntoni J Duleba
Apr 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Anna SokalskaAntoni J Duleba
Jan 23, 2013·The Journal of Clinical Endocrinology and Metabolism·Anna SokalskaAntoni J Duleba
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Sep 4, 2012·Fertility and Sterility·Sérgio Reis SoaresAntonio Pellicer
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Jun 23, 2011·Reproductive Sciences·Hugh S TaylorAntoni J Duleba
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