PMID: 9186837May 1, 1997Paper

In vitro effects of cholecystokinin fragments on human gallbladders. Evidence for an altered CCK-receptor structure in a subgroup of patients with gallstones

Journal of Hepatology
H SchneiderE Hanisch

Abstract

This study addresses cholecystokinin (CCK)-receptor alterations in stone-diseased and stone-free human gallbladders using different CCK-fragments. Serosa-free muscle strips were mounted in a modified Krebs-Henseleit-solution of 37 degrees C and aerated with carbogen. The following concentrations of CCK-fragments (CCK 26-33, N-Acetyl CCK 27-33 sulf., CCK 26-29 sulf., CCK 25-33 sulf.) were achieved: 0.1 nmol, 0.5 nmol, 2 nmol, 10 nmol, 100 nmol. Stone-diseased gallbladders were classified into two groups based on their in vitro reaction to CCK 26-33 (CCK-octapeptide). Muscle strips not contracting below 10 nmol were assigned to the subcontractor group. Histologically scarification, necrosis and signs of severe inflammation of the mucosa were seen in 76.9% of this group. Those starting contractions at 0.1 nmol (like the control group) were called the contractor group. This group had a shallow mucosa and mild inflammatory signs in 54.5%. The sub-contractor group showed higher spontaneous phasic activity at lower tonic activity than the contractor and control groups. In the sub-contractor group CCK 27-33 caused several times higher contractions than all other fragments. A maximal contraction level in the contractor and control group...Continue Reading

References

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Citations

Jun 12, 2004·Current Gastroenterology Reports·David Q-H Wang, Nezam H Afdhal
Mar 7, 2001·Regulatory Peptides·S C HuangS M Huang
Sep 17, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·H WittenburgM C Carey
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Frank Lammert, Tilman Sauerbruch
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·P PortincasaG Palasciano
May 10, 2012·Gut and Liver·Laura M Stinton, Eldon A Shaffer
Dec 8, 2011·Journal of Neurogastroenterology and Motility·Chung Owyang, Andrea Heldsinger
Jun 12, 2004·Current Gastroenterology Reports·Piero PortincasaGerard P vanBerge-Henegouwen
Apr 12, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J GayL Buéno
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Piero PortincasaDavid Q-H Wang
Apr 15, 2008·Current Opinion in Gastroenterology·Aksana Höblinger, Frank Lammert
Feb 14, 2002·Physiological Genomics·Henning WittenburgBeverly Paigen
Nov 28, 2006·Best Practice & Research. Clinical Gastroenterology·Frank Grünhage, Frank Lammert
Mar 1, 2008·Journal of Hepatology·Frank Lammert, Juan-Francisco Miquel
May 19, 2010·Gastroenterology Clinics of North America·Helen H WangDavid Q H Wang

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