PMID: 11912075Mar 26, 2002Paper

In vitro effects of ethanol, acetaldehyde and fatty acid ethyl esters on human erythrocytes

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
O V TyulinaP Johnson

Abstract

In vitro experiments were performed to determine if ethanol was metabolized by human erythrocytes and to investigate if ethanol or its metabolites, acetaldehyde and fatty acid ethyl esters, affected erythrocyte morphology and stability. No detectable metabolism of ethanol was found in erythrocytes, although ethanol itself caused an elevated rate of spontaneous haemolysis in erythrocyte preparations. Physiologically attainable levels of ethanol were found to stabilize erythrocytes against haemolysis induced by sodium hypochlorite, and the presence of ethanol caused a decrease in erythrocyte reactive oxygen species levels, although the mechanism for such a process is unknown. Both physiologically attainable and higher levels of acetaldehyde had no effects on erythrocyte morphology and stability even after a 16 h exposure. Fatty acid ethyl esters caused structural changes and instability in erythrocytes in vitro, but whether such changes occur in vivo has not been established. The results of these studies suggest that the deleterious effects of ethanol consumption on erythrocytes in vivo may be, at least in part, the result of direct effects of unmetabolized ethanol on erythrocyte components.

Citations

May 21, 2005·Alcohol·Bhupendra S KaphaliaG A S Ansari
Nov 25, 2003·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·N C SukulA Sukul
Jan 24, 2003·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Cynthia F Bearer
Feb 6, 2008·Basic & Clinical Pharmacology & Toxicology·Ivan KosalecNevenka Kopjar
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·D M Boothe, J Perkins
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hikmet Hakan AydinYücel Batur
Apr 25, 2006·Biochimica Et Biophysica Acta·Olga V TyulinaPeter Johnson
Jun 16, 2007·Life Sciences·Subir Kumar Das, D M Vasudevan
Jun 19, 2004·Addiction Biology·Onni Niemelä, Seppo Parkkila
Feb 4, 2003·Journal of Lipid Research·Catherine A BestMichael Laposata
May 12, 2010·American Journal of Physiology. Cell Physiology·Asya MakhroAnna Bogdanova
Jun 16, 2011·Molecular Biology Reports·Ahmet KahramanTülay Köken

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