PMID: 6165387Dec 5, 1980Paper

In vitro effects of ethanol and ethanol metabolism in the rat pancreas

Biochimica Et Biophysica Acta
P Calderon-AttasJ Christophe

Abstract

1. Ethanol provoked no effect on basal and carbamylcholine-stimulated secretion of amylase from rat pancreatic fragments incubated for 1 h. 2. Ethanol enhanced in vitro synthesis of fatty acids from [1-14C]acetate and from 3H2O by 110 and 166%, respectively. The spectrum of fatty acids labelled with [1-14C]acetate in the presence of ethanol pointed to a stimulation of the malonic acid pathway, whereas the elongation of polyenoic fatty acids was unaltered. The in vitro metabolism of [1-14C]ethanol indicates that ethanol itself contributed carbon atoms to lipogenesis dose-dependently. 3. The conversion of [U-14C]glucose into sn-glycero 3-phosphate and the esterification of fatty acids into phosphatidic acids and triacylglycerols was stimulated whereas net lipolysis was unaffected. The oxidation of [U-14C]-glucose and of [1-14C]acetate to 14CO2 and the beta-oxidation of [1-14C]palmitate was reduced by 24--26%. 4. Maximal effects were produced by a 100--200 mM ethanol concentration and the concentration of ethanol evoking a similar half-maximal alteration of most processes was 20--30 mM. A 10--20 min lag period was required for the full development of these effects. 5. It is concluded that ethanol at low concentration alters the re...Continue Reading

References

Dec 15, 1978·The Biochemical Journal·M J Savolainen, I E Hassinen
Sep 28, 1979·Biochimica Et Biophysica Acta·P CalderonJ Christophe
Jan 1, 1977·Nutrition and Metabolism·H Sarles
Feb 15, 1973·The New England Journal of Medicine·C S Lieber
Nov 1, 1974·The Medical Clinics of North America·H Sarles, O Tiscornia
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·A VandermeersJ Christophe
Oct 1, 1972·The American Journal of Digestive Diseases·C MottL Gullo
Oct 1, 1967·The Biochemical Journal·O A Forsander
Feb 1, 1961·The Journal of Clinical Investigation·C S LIEBER, R SCHMID
Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·E A NIKKILAE, K OJALA
Sep 1, 1962·The American Journal of Medicine·C S LIEBER, C S DAVIDSON

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Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R BühlerJ P Von Wartburg
Jun 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·I de DiosM A Manso
Oct 15, 1987·Biochemical Pharmacology·B A Chapman, N R Pattinson
Dec 10, 2015·Pancreas·Wenjuan YangChengwei Tang
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·E Niebergall-RothM V Singer
Aug 1, 1985·Scandinavian Journal of Gastroenterology·H Sarles
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·H Sarles
May 15, 1988·Biochemical Pharmacology·B A Chapman, N R Pattinson

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