In vitro effects of growth factors on rat germ cell RNA synthesis and their modulation by Sertoli cell-secreted proteins.

Molecular Reproduction and Development
S FradinM A Drosdowsky

Abstract

In vitro rat germ cell RNA synthesis is influenced by growth factors. Basic fibroblast growth factor (0.1 to 100 ng/ml) increases [3H]uridine incorporation in round spermatids (RS) but not in pachytene spermatocytes (PS); this effect is potentiated by insulin (10 micrograms/ml) and blocked in the presence of Sertoli cell-secreted proteins (SCSP). Somatomedin C (0.1 to 100 ng/ml) exhibits a similar effect when used alone without an influence by SCSP. Transforming growth factor beta (0.1 to 10 ng/ml) acts on both cell types, but SCSP amplify this effect only in PS. These data suggest that growth factors synthesized in situ may play a role in the germ cell development and that their effects are modulated by SCSP.

References

Nov 1, 1979·Experimental Cell Research·J P Mather, G H Sato
Nov 1, 1979·Journal of Reproduction and Fertility·F PalombiM Stefanini
Oct 1, 1986·Molecular and Cellular Endocrinology·M TakahashiP K Donahoe
Apr 1, 1987·International Journal of Andrology·S A KhanE M Ritzén
Aug 1, 1987·Endocrinology·G NeufeldD Gospodarowicz
Jul 31, 1987·Biochemical and Biophysical Research Communications·O AvalletJ M Saez
Feb 1, 1987·Molecular and Cellular Endocrinology·N UenoR Guillemin
Jun 1, 1969·Journal of Cellular Physiology·R G Miller, R A Phillips
Mar 30, 1982·Biochemical and Biophysical Research Communications·K D BrownB P Setchell
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L L Tres, A L Kierszenbaum
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L A FeigM Klagsbrun
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W W WrightC W Bardin

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Citations

Dec 1, 1993·Molecular Reproduction and Development·K L LovelandD M De Kretser
Jan 1, 1991·Annals of the New York Academy of Sciences·D A O'BrienE M Eddy
Mar 21, 2003·Reproductive Biology and Endocrinology : RB&E·Bart L HaagmansKatja J Teerds
May 1, 1991·Breast Cancer Research and Treatment·H S SmithB M Ljung

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