In vitro effects of HgCl2 on murine lymphocytes. II. Selective activation of T cells expressing certain V beta TCR

International Immunology
Y Jiang, G Möller

Abstract

In vivo administration of HgCl2 causes autoimmune manifestations in susceptible rats and mice. We have previously shown that mercury is a unique molecule that can primarily activate murine T lymphocytes to transformation and proliferation in vitro. To test whether a specific TCR repertoire predisposes the autoimmune development induced by HgCl2 and our hypothesis that mercury may function as a superantigen, we examined the TCR V beta repertoire in HgCl2-stimulated T cells from the responder BALB/c or SJL mice and the non-responder DBA/2 mice. We found a selective activation of T cells bearing a certain set of TCR B beta chains in response to HgCl2, e.g. V beta 6, V beta 8, V beta 10 and V beta 14 in the BALB/c strain. Moreover, depletion of V beta 8+ T cells, a family predominantly expanded in the BALB/c strain upon HgCl2 stimulation, profoundly inhibited the response to HgCl2 in this strain. An alternative selection of V beta segments, involving V beta 6, V beta 7 and V beta 14, was observed in the SJL strain in which the V beta 8 family is genetically deleted. Mechanism(s) whereby mercury modulates the immune system under a stringent genetic control and a possible therapeutic regime against mercury-induced autoimmune disease ...Continue Reading

Citations

Nov 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yubin ZhangDavid A Lawrence
Nov 27, 1999·Drug Metabolism Reviews·K M GilbertN R Pumford
Dec 17, 2008·Annals of the New York Academy of Sciences·Jaya Vas, Marc Monestier
Sep 9, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A LofteniusE Möller

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