PMID: 174821Feb 6, 1976

In vitro effects of histamine liberator compound 48/80 on rat superior cervical ganglia with special regard to the small granule-containing cells

Cell and Tissue Research
H BehrendtH Cramer


The effect of the histamine liberator compound 48/80 on the rat superior cervical ganglia in vitro has been investigated. After incubation of the ganglia with compound 48/80: (1) ganglionic mast cells degranulate in the same manner as in other tissues; (2) cell bodies of the postganglionic neurons are not affected by compound 48/80; (3) there is evidence that ganglionic interneurons, the monoamine-containing cells are activated. The ultrastructural aspects of this process are characterized by degranulation of perikarya and accumulation of dense core vesicles in cell processes and in terminals adjacent to presynaptic membranes. These vesicles vary in size between 200-800 A in diameter. They may represent storage sites of the neuro-transmitter complexes that have undergone exocytosis. The results are discussed with special reference to models of exocytotic processes involving the adrenergic transmitter. It is concluded that monoamine-containing cells represent interneurons in sympathetic ganglia which inhibit ganglionic transmission and which are stimulated by low concentrations of compound 48/80 in vitro.


Jan 1, 1990·Journal of Neural Transmission. General Section·J C FolanC Heym
Mar 31, 1992·European Journal of Pharmacology·T J Heppner, J F Fiekers
May 1, 1989·Pharmacology, Biochemistry, and Behavior·S J LewisB Jarrott
Aug 1, 1980·Veterinary Immunology and Immunopathology·H Buschmann, S Pawlas


Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·T LindlH Cramer
Nov 23, 1973·Brain Research·A Dahlström
Jan 1, 1968·International Review of Cytology·Y Olsson
Nov 16, 1973·Nature·M J Brimble, D I Wallis
Jan 1, 1973·Journal of the Neurological Sciences·I S CooperJ M Waltz
Mar 1, 1955·British Journal of Pharmacology and Chemotherapy·S B GERTNER
Sep 1, 1951·British Journal of Pharmacology and Chemotherapy·W D M PATON

Related Concepts

Mast Cell
Synaptic Vesicles
Synaptic Transmission
Cytoplasmic Granules
Autonomic Ganglion
Rats, Laboratory

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