In vitro effects of naloxone on T-lymphocyte-dependent antibacterial activity in hepatitis C virus (HCV) infected patients and in inflammatory bowel disease (IBD) patients

Immunopharmacology and Immunotoxicology
L AmatiE Jirillo

Abstract

Naloxone acts as an opioid antagonist, displacing opioid drugs from cellular receptors. Among opioid substances, beta-endorphins are able to bind to several cell receptors, even including those expressed by immune cells. In this respect, evidence has been provided that in the course of viral infections, as well as in patients with ulcerative colitis high levels of beta-endorphins are detectable. Here, peripheral blood lymphocytes (PBL) from 21 HCV infected patients and 14 patients with IBD, respectively, were incubated with Naloxone and Naloxone + Ca2+ in order to evaluate a putative modulation of PBL-mediated antibacterial activity. In fact, previous studies have demonstrated a reduction of this T-cell activity in HCV and IBD patients. In general terms, the above treatment led to a recovery of the depressed antibacterial activity. In some cases, increase in T lymphocyte function was obtained with Naloxone alone, while in other cases the combination Naloxone + Ca2+ gave rise to a restorative effect. Of note, in some instances, lymphocytes were unresponsive to pharmacological modulation. The overall results suggest that beta-endorphins may down modulate T-cell antibacterial response in HCV and in IBD patients by saturating perip...Continue Reading

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Citations

Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Aug 27, 2009·International Immunopharmacology·Agheel Tabar Molla HassanSeyed Mahmoud Hashemi
Jul 26, 2016·Frontiers in Microbiology·Alireza TahamtanVahid Salimi
Dec 19, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Christoph RobierManfred Neubauer
Jun 28, 2003·Natural Product Reports·Kenneth W Bentley

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