In vitro effects of recombinant human granulocyte-macrophage colony-stimulating factor (RhGM-CSF) on polymorphonuclear cell (PMN) and monocyte (MO) functional capacities in ovarian cancer patients versus human volunteers

Immunopharmacology and Immunotoxicology
M AltamuraE Jirillo

Abstract

Human polymorphonuclear cells (PMN) and monocytes (MO) from four ovarian cancer patients and seventeen normal donors were in vitro pretreated with different concentrations (25, 50 and 100 IU, respectively) of rhGM-CSF. Phagocytosis and killing of PMN and MO as well as PMN polarization were evaluated in cancer patients before treatment (T0) and at the end of each chemotherapeutic cycle (T1, T2, T3 and T4, respectively) in comparison with normal donors. RhGM-CSF did not affect phagocytosis and killing of PMN and MO. On the other hand, this cytokine was per se endowed with the capacity to enhance PMN polarization in both cancer patients (at T2 interval) and normal donors.

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Citations

Apr 5, 2003·Immunopharmacology and Immunotoxicology·L PassantinoG Ranieri
Oct 15, 2010·Journal of Cellular Physiology·Tatsuya MorishimaToshio Heike
Nov 9, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Ana Luisa de Oliveira Bonnano AbibAna Cristina Breithaupt-Faloppa
Jan 13, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·O T PajuloJ A Viljanto

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