In vitro effects of Trichinella spiralis on muscle cells

Journal of Helminthology
R K Leung, R C Ko

Abstract

Introduction of excretory/secretory (ES) products of both infective-stage and newborn larvae of Trichinella spiralis into cultures of primary rat myocytes elicited morphological and structural changes in the myotubes. They appeared more granular, thinner, and failed to form networks. The most prominent lesion was the formation of 'nodular' structures, each bearing an enlarged nucleus, along the myotubes. Each node contained numerous cavities enclosed by an intact sarcolemma. Co-culture of myocytes with newborn larvae also elicited nodular formation but each node contained a large central cavity encircled by smaller ones. An immunocytolocalization study using IFAT and laser confocal microscopy showed the presence of parasitic epitopes inside the nodes. However, ES products from adult worms did not affect the myotubes.

References

Mar 1, 1978·The Anatomical Record·A C Platzer
Mar 1, 1975·American Journal of Surgery·C A HeiskellJ M Beal
Dec 1, 1992·Veterinary Parasitology·A Criado-FornelioF Rodríguez-Caabeiro
Dec 1, 1992·Veterinary Parasitology·K P Baker, S Elharam
Sep 1, 1989·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D J KelvinJ A Connolly
Jan 1, 1988·Molecular and Biochemical Parasitology·G Chaudhuri, K P Chang
Mar 1, 1988·The American Journal of Anatomy·M OntellD Hughes

❮ Previous
Next ❯

Citations

Mar 9, 2004·Molecular and Biochemical Parasitology·Daniel GareBernadette Connolly
Sep 30, 2006·International Journal for Parasitology·Mark W RobinsonBernadette Connolly

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Jing CuiDeng Zhang
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Shu-Wei WangLi Wang
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Li-qun MaoYi Sun
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Xiu-ping WuPascal Boireau
© 2021 Meta ULC. All rights reserved