Abstract
Introduction of excretory/secretory (ES) products of both infective-stage and newborn larvae of Trichinella spiralis into cultures of primary rat myocytes elicited morphological and structural changes in the myotubes. They appeared more granular, thinner, and failed to form networks. The most prominent lesion was the formation of 'nodular' structures, each bearing an enlarged nucleus, along the myotubes. Each node contained numerous cavities enclosed by an intact sarcolemma. Co-culture of myocytes with newborn larvae also elicited nodular formation but each node contained a large central cavity encircled by smaller ones. An immunocytolocalization study using IFAT and laser confocal microscopy showed the presence of parasitic epitopes inside the nodes. However, ES products from adult worms did not affect the myotubes.
References
Mar 1, 1978·The Anatomical Record·A C Platzer
Mar 1, 1975·American Journal of Surgery·C A HeiskellJ M Beal
Nov 1, 1992·Molecular and Biochemical Parasitology·J A Cooper, H Bujard
Dec 1, 1992·Veterinary Parasitology·A Criado-FornelioF Rodríguez-Caabeiro
Dec 1, 1992·Veterinary Parasitology·K P Baker, S Elharam
Sep 1, 1992·The Journal of Cell Biology·K W TsimM M Salpeter
Feb 1, 1991·Parasitology·D L LeeM H Yeung
Sep 1, 1989·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D J KelvinJ A Connolly
Jan 1, 1988·Molecular and Biochemical Parasitology·G Chaudhuri, K P Chang
Mar 1, 1988·The American Journal of Anatomy·M OntellD Hughes
Jan 1, 1987·Tissue & Cell·D L Lee, R R Shivers
Dec 24, 1987·Cell·R L DavisA B Lassar
Oct 1, 1985·The Biochemical Journal·J H McKerrowS Pino-Heiss
Nov 1, 1983·Veterinary Parasitology·H R GambleK D Murrell
Aug 1, 1995·Parasitology·V K TodorovaM W Kennedy
Feb 1, 1994·Parasitology·R C KoH Compton
Jan 1, 1996·Parasitology·R C Ko, L Fan
Citations
Mar 9, 2004·Molecular and Biochemical Parasitology·Daniel GareBernadette Connolly
Jul 13, 2002·Parasitology International·Zhiliang WuYuzo Takahashi
Dec 13, 2005·Parasitology Research·Catherine TrapPascal Boireau
Oct 2, 2001·Parasitology·C H Mak, R C Ko
Dec 28, 2011·Parasitology Research·Xue BaiMingyuan Liu
Sep 17, 2013·Parasitology Research·Rositsa MilchevaPavel Babál
Jul 5, 2005·Veterinary Parasitology·Mark W RobinsonBernadette Connolly
Sep 30, 2006·International Journal for Parasitology·Mark W RobinsonBernadette Connolly
Oct 13, 2005·Proteomics·Mark W Robinson, Bernadette Connolly
Mar 30, 1999·European Journal of Biochemistry·C H Mak, R C Ko