In vitro effects of trichothecenes on human dendritic cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
N HymeryD Parent-Massin

Abstract

The aim of this work was to study the in vitro effects of trichothecenes on human dendritic cells. Trichothecenes are mycotoxins produced by fungi such as Fusarium, Myrothecium, and Stachybotrys. Two aspects have been explored in this work: the cytotoxicity of trichothecenes on immature dendritic cells to determine IC 50 (inhibition concentration), and the effects of trichothecenes on dendritic cell maturation process. Two mycotoxins (T-2 and DON) known to be immunotoxic have been tested on a model of monocyte-derived dendritic cells culture. Cytotoxic effects of T-2 toxin and DON on immature dendritic cells showed that DON is less potent than T-2 toxin. The exposure to trichothecenes during dendritic cell maturation upon addition of LPS or TNF-alpha markedly inhibited the up-regulation of maturation markers such as CD-86, HLA-DR and CCR7. Features of LPS or TNF-alpha -mediated maturation of dendritic cells, such as IL-10 and IL-12 secretions and endocytosis, were also impaired in response to trichothecenes treatment. These results suggest trichothecenes have adverse effects on dendritic cells and dendritic cell maturation process.

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Citations

May 15, 2007·Current Opinion in Infectious Diseases·Rod J Hay
Jan 1, 2013·Toxicology Letters·Chanemougasoundharam Arunachalam, Fiona M Doohan
Sep 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Manjari Chaudhary, P V Lakshmana Rao
Jul 29, 2009·Toxicon : Official Journal of the International Society on Toxinology·D LuongoM Rossi
May 16, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N HymeryD Parent-Massin
Oct 31, 2007·European Journal of Internal Medicine·Stephen J Genuis
Jan 24, 2008·Journal of Evaluation in Clinical Practice·Stephen J Genuis
Feb 22, 2013·Molecular Nutrition & Food Research·Thierry GauthierIsabelle P Oswald
Dec 30, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhihua RenJing Fang
May 21, 2013·Toxicon : Official Journal of the International Society on Toxinology·A S FicheuxD Parent-Massin
Sep 25, 2016·Archives of Toxicology·Delphine PayrosIsabelle P Oswald
Apr 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał DąbrowskiMaciej Tadeusz Gajęcki
Aug 20, 2017·Cell Biology and Toxicology·Marie-Caroline SmithNolwenn Hymery
Aug 1, 2008·Current Protocols in Toxicology·Dominique Parent-Massin, Yann Sibiril
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May 1, 2021·Frontiers in Microbiology·Rhys BrownJonathan P Richardson

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