In vitro effects of triclosan and methyl-triclosan on the marine gastropod Haliotis tuberculata

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Beatrice GaumeGilles Bedoux

Abstract

Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether; TCS) is an antibacterial agent incorporated in a wide variety of household and personal care products. Because of its partial elimination in sewage treatment plants, TCS is commonly detected in natural waters and sediments. Moreover, due to its high hydrophobicity, TCS accumulates in fatty tissues in various aquatic organisms. TCS can be converted into methyl-triclosan (2,4,4'-trichloro-2'-methoxydiphenyl ether; MTCS) after biological methylation. In this study, the acute cytotoxicity of TCS and MTCS in short-term in vitro experiments was assessed on cell cultures from the European abalone Haliotis tuberculata. The results showed that morphology and density of hemocyte are affected from a concentration of 8 μM TCS. Using the XTT reduction assay, TCS has been demonstrated to decrease hemocyte metabolism activity in a dose- and time-dependent exposure. The IC(50) was evaluated at 6 μM for both hemocyte and gill cells after a 24 h-incubation with TCS. A significant cytotoxicity of MTCS was also observed from 4 μM in 24 h-old hemocyte culture. Our results reveal a toxic effect of TCS and MTCS on immune (hemocytes) and/or respiratory cells (gill cells) of the abalone, species li...Continue Reading

References

May 12, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I Domart-CoulonM Khalanski
Aug 17, 2001·FEMS Microbiology Letters·H P Schweizer
May 11, 2002·Chemosphere·Margaretha Adolfsson-EriciJoachim Sturve
Jul 12, 2002·Environmental Toxicology and Chemistry·David R OrvosVirginia Cunningham
May 31, 2003·Environmental Science & Technology·Brittan A WilsonCynthia K Larive
Sep 27, 2003·Water Research·Darius SabaliunasWilliam S Eckhoff
Apr 10, 2004·Science·Andrew S MountD Snider
Jun 17, 2005·Archives of Environmental Contamination and Toxicology·Kai Bester
Dec 27, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Brian QuinnCarmel Mothersill
Dec 21, 2006·Bulletin of Environmental Contamination and Toxicology·J Gorski, D Nugegoda
Mar 10, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Laura CanesiAntonio Marcomini
Apr 3, 2007·Environmental Technology·M V GanesanT R Sreekrishnan
Aug 23, 2007·Environmental Science & Technology·Niina M VienoLeif Kronberg
Sep 12, 2007·Archives of Environmental Contamination and Toxicology·Marie E DeLorenzo, Jessica Fleming
Feb 9, 2008·Integrated Environmental Assessment and Management·Marie CapdevielleDaniel Woltering
Feb 22, 2008·Fish & Shellfish Immunology·Marie-Agnès TraversChristine Paillard
Aug 19, 2008·Ecotoxicology and Environmental Safety·Feng LiuQi-Xing Zhou
Oct 1, 2008·Aquatic Toxicology·Stephanie FranzMechthild Schmitt-Jansen
Nov 13, 2008·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Arata HaradaYutaka Suzuki
Jan 28, 2009·Chemosphere·Singaram GopalakrishnanKe-Jian Wang
Feb 24, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·A BinelliA Provini
Mar 27, 2009·Environmental Toxicology and Chemistry·Alejandro J RamirezC Kevin Chambliss
Jun 16, 2009·Marine Environmental Research·J Evan Ward, Dustin J Kach
Sep 17, 2009·Archives of Environmental Contamination and Toxicology·Kurunthachalam Senthil KumarKenneth S Sajwan
Jan 5, 2010·Journal - American Water Works Association·Talia E Chalew, Rolf U Halden
Apr 10, 2010·Critical Reviews in Toxicology·Joseph V RodricksAnnette M Shipp
Apr 27, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nicole M PalenskeEdward M Dzialowski

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Citations

Aug 10, 2013·Cytotechnology·Matthew O'NeillStéphanie Auzoux-Bordenave
Jun 13, 2013·Cytotechnology·Delphine PichonStéphanie Auzoux-Bordenave
Nov 28, 2015·Cytotechnology·Rim Ladhar-Chaabouni, Amel Hamza-Chaffai
Aug 19, 2014·Environmental Science and Pollution Research International·Rim Ladhar-ChaabouniAmel Hamza-Chaffai
Aug 15, 2015·Bulletin of Environmental Contamination and Toxicology·Lei ChenTing Yu
Nov 19, 2013·Ecotoxicology and Environmental Safety·Jinik HwangTaek-Kyun Lee
Sep 13, 2016·Environmental Science and Pollution Research International·Emma Prichard, Elise F Granek
Nov 29, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Lisa M Weatherly, Julie A Gosse
Dec 4, 2019·Analytical and Bioanalytical Chemistry·Amal Guesmi, Lekha Sleno
Dec 9, 2020·International Journal of Molecular Sciences·Timothy AbbottCigdem Eskicioglu
Mar 20, 2021·The Science of the Total Environment·Amalia RosnerSébastien Cambier

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