PMID: 7008482Feb 1, 1981

In vitro effects of various metabolic inhibitors on the formation of inactive renin and the loss of renin in rabbit uterine tissue

Acta Endocrinologica
J Jørgensen

Abstract

A pronounced formation of renin occurs during incubation of non-pregnant uterine tissue slices in vitro. The synthesized renin appears in an enzymatically inactive form, which can be activated by acidification. Prior to incubation only a small fraction of inactive renin is present. The formation of inactive renin is blocked by puromycin and by inhibition of energy metabolism, indicating a de novo synthesis. A similar pattern of inhibition prevails the modest formation of inactive renin in post-partum uterus. The marked loss of active renin seen during incubation of post-partum uterine tissue is partly prevented by an inhibition of energy metabolism. Potent inhibitors are iodoacetate and chloroquine. These findings are in accordance with lysosomal engagement in the inactivation of renin. Incubated kidney cortex tissue shows only a minor loss of renin during incubation. This loss is uninfluenced by attempts to block it.

Citations

Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·D B Gordon

Related Concepts

Nivaquine
Dinitrophenols
Energy Metabolism
Glucose, (beta-D)-Isomer
Iodoacetic Acids
Structure of Cortex of Kidney
Lysosomes
Puromycin Dihydrochloride
Preprorenin
Uterus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.