In vitro effects of vitamin C and selenium on NK activity of patients with beta-thalassemia major

Pediatric Hematology and Oncology
Belkis AtaseverZeynep Karakas

Abstract

In this study, the in vitro effects of vitamin C and selenium on natural killer (NK) cell activity of ss-thalassemia major patients was investigated. At first, significant decreased NK activity was found at E:T ratios of 1:1, 5:1, and 10:1 in whole thalassemia patients. Low-dose selenium treatment enhanced NK activity in patients but there was no change in the control group. High-dose selenium decreased NK activity significantly in splenectomized patients. Different doses vitamin C enhanced NK activity significantly in both splenectomized and unsplenectomized patients. According to these results, selenium dosage should be arranged carefully in thalassemia patients, whereas vitamin C can be used confidently.

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Citations

Dec 20, 2015·International Journal of Immunopathology and Pharmacology·Hou DiandongCai Liping
Feb 25, 2014·International Journal of Biometeorology·Ananda Raj GoswamiTusharkanti Ghosh
Oct 31, 2019·European Journal of Microbiology & Immunology·Soraya MousaviMarkus M Heimesaat
Dec 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan F ClinthorneElizabeth M Gardner
Mar 15, 2018·Antioxidants·Gwendolyn N Y van GorkomGerard M J Bos
Nov 25, 2020·Future Science OA·Annette d'ArqomAndi Muh Rahul Alfaidin

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