PMID: 9532274Apr 9, 1998Paper

In vitro efficacy of a hydrophilic central venous catheter loaded with silver to prevent microbial colonization

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
N GatterB Jansen

Abstract

A method was developed to load the surface of a central venous catheter with silver to prevent bacterial colonization. Silver confers a broad antimicrobial activity with a relatively low risk of resistance. Catheters were incubated with a silver nitrate solution in different concentrations. The solvent, incubation temperature and incubation period were varied to examine the influence on the catheter loading. With increasing incubation temperature, time and concentration of silver nitrate, higher rates of silver elution were observed by atomic absorption spectroscopy. Furthermore, by using ethanol-water as a solvent instead of pure water, the amount of silver bound to the catheter surface was enhanced. The release of silver from the catheter surface is mainly controlled by first order kinetics. Antimicrobial efficacy of the modified catheter, in comparison to unloaded catheters, was tested in a stationary and a dynamic model with different microorganisms. Adherence experiments with Candida albicans showed almost complete inhibition of growth during a period of 72 hours, including initial adherence. While initial adherence of bacteria could not be prevented, these experiments showed an excellent reduction of bacterial colonizatio...Continue Reading

References

Aug 1, 1992·The Journal of Antimicrobial Chemotherapy·B JansenG Pulverer
May 1, 1991·Plastic and Reconstructive Surgery·E C SmootN Debs
Feb 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S E Tebbs, T S Elliott
Jan 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·C R BabycosW R Webb

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Citations

Oct 30, 2009·Journal of the Royal Society, Interface·Viviana Mouriño, Aldo R Boccaccini
May 23, 2002·Antimicrobial Agents and Chemotherapy·Maria BellantoneLarry L Hench
Aug 12, 2000·Journal of Bacteriology·P J Riggle, C A Kumamoto
Apr 16, 2002·Molecular Microbiology·Friedrich Götz
Dec 15, 2005·The International Journal of Artificial Organs·C von EiffB Jansen
Mar 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shunmugaperumal TamilvananAnnick Ludwig

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