In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts

Antimicrobial Agents and Chemotherapy
Anjan DebnathJames H McKerrow

Abstract

Painful blinding keratitis and fatal granulomatous amebic encephalitis are caused by the free-living amebae Acanthamoeba spp. Several prescription eye medications are used to treat Acanthamoeba keratitis, but the infection can be difficult to control because of recurrence of infection. For the treatment of encephalitis, no single drug was found useful, and in spite of the use of a combination of multiple drugs, the mortality rate remains high. Therefore, efficient, novel drugs are urgently needed for the treatment of amebic keratitis and granulomatous amebic encephalitis. In this study, we identified corifungin, a water-soluble polyene macrolide, as amebicidal. In vitro, it was effective against both the trophozoites and the cysts. Transmission electron microscopy of Acanthamoeba castellanii incubated with corifungin showed the presence of swollen mitochondria, electron-dense granules, degeneration of cytoplasm architecture, and loss of nuclear chromatin structure. These changes were followed by lysis of amebae. Corifungin also induced the encystment process of A. castellanii. There were alterations in the cyst cell wall followed by lysis of the cysts. Corifungin is a promising therapeutic option for keratitis and granulomatous...Continue Reading

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Citations

Dec 23, 2014·Expert Opinion on Therapeutic Patents·Alice Machado-SilvaRubén Dario Sinisterra
Apr 30, 2017·Applied and Environmental Microbiology·Javier A Benavides-Montaño, Viveka Vadyvaloo
Aug 13, 2014·Antimicrobial Agents and Chemotherapy·Bijay Kumar JhaWon-Ki Baek
Mar 21, 2020·PLoS Neglected Tropical Diseases·Gretchen EhrenkauferUpinder Singh
May 28, 2020·Pathogens·Hany M ElsheikhaNaveed Ahmed Khan
Sep 3, 2021·Medicinal Research Reviews·Usman AhmedNaveed Ahmed Khan
Oct 5, 2021·Pathogens and Global Health·Mohammad Ridwane MungrooRuqaiyyah Siddiqui

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