In vitro elimination of anti-infective drugs by the Seraph® 100 Microbind® affinity blood filter

Clinical Kidney Journal
Julius J SchmidtJan T Kielstein

Abstract

In August 2019, the European Union licensed the first ever haemoperfusion device aimed to reduce pathogens in the blood. The core of the adsorber consists of ultra-high molecular weight polyethylene beads with endpoint-attached heparin. These beads utilize pathogen inherent adhesion mechanisms to reduce pathogen load. So far, it is unknown whether the device has an effect on anti-infective drug concentrations. The aim of this study was to investigate the in vitro adsorption of multiple anti-infective drugs from human plasma. In this in vitro study, 18 anti-infective drugs were administered to human donor plasma and pumped through the heparin-coated pathogen adsorber (Seraph® 100 Microbind®Affinity Blood Filter; ExThera Medical Corp., Martinez, CA, USA) at a plasma flow rate of 250 mL/min for 60 min. Pre- and post-adsorber plasma samples were quantified after 5, 15, 30 and 60 min. We found a reduction ratio (RR) in anti-infective plasma levels between -1% and 62%. This decrease occurred mainly in the first 5 min of the experiment (RR0-5 -4 to 62%). Mean plasma clearance rates ranged between -11.93 mL/min (fluconazole) and 4.86 mL/min (clindamycin). The highest RRs were measured for aminoglycosides (tobramycin 62% and gentamycin ...Continue Reading

References

Jul 26, 2012·Environmental Science & Technology·Stephen KrollKurosch Rezwan
Nov 5, 2014·Frontiers in Microbiology·Nadim CassirPhilippe Brouqui
Nov 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Marya D ZilberbergMarin H Kollef
Dec 14, 2018·The International Journal of Artificial Organs·Christina KönigAxel Nierhaus

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Citations

Jun 20, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Malin-Theres SefferJan T Kielstein
Apr 20, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·Anke PapeReinhard Brunkhorst

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Software Mentioned

Seraph

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