In vitro enhancement of antibody responses by T delta cells expressing IgD receptors

Cellular Immunology
Y J Yang, R F Coico

Abstract

Previous in vivo studies have shown that murine T cells induced to express receptors specific for IgD (IgD-R) have humoral immunoaugmenting properties with respect to both primary and secondary antibody responses to various antigens. Such murine IgD-R+ T cells (T delta cells) belong to the CD4+ T cell population in contrast with human T delta cells which also include CD8+ cells. The purpose of these studies was to develop an in vitro assay system to examine the mechanism by which T delta cells facilitate enhanced antibody responses. Our studies demonstrate that B cell responses to both soluble and particulate antigens can, indeed, be enhanced in vitro by coculture with T cells previously induced to express IgD-R. This in vitro effect requires cognate interaction between T and B cells and is dependent on the presence of adherent cells or IL-1. T cell priming with antigen, while not a prerequisite, was found to result in more effective T delta-B cell interactions compared with naive T delta cells. Finally, evidence was obtained in support of an adhesion-mediated T delta-B cell interaction since the immunoaugmenting properties of T cells expressing IgD-R are completely blocked by the addition of very low doses of monomeric IgD to ...Continue Reading

Citations

Feb 26, 1998·Immunological Reviews·C D Swenson, G J Thorbecke
May 30, 2003·Journal of Leukocyte Biology·Seetha M Lakshmi Tamma, Richard F Coico
Aug 26, 1998·European Journal of Immunology·C D SwensonA R Amin
Apr 3, 2001·Molecular Immunology·J L Preud'hommeE Lelièvre

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