PMID: 15347953Sep 7, 2004Paper

In vitro evaluation of a new polymethylmethacrylate cement reinforced with hydroxyapatite

Journal of Materials Science. Materials in Medicine
Matthew J DalbyWilliam Bonfield

Abstract

The nature of the orthopedic implant surface affects the interaction between cells and subsequent bone formation. The bone/cement interface in cement-held prostheses is considered to be the main cause of fracture leading to implant revision. It is thought that the introduction of a bioactive phase, such as hydroxyapatite (HA), to cement may permit a stronger implant by encouraging direct bone apposition rather than encapsulation of the implant by fibrous tissue. Thus, a poly(methylmethacrylate) (PMMA) cement incorporating 17.5% HA by weight has been investigated. In this study, in order to analyze the interaction at the cellular level, the in vitro biological response of the HA/PMMA to a similar PMMA without HA incorporation has been studied. Primary human osteoblast-like cells (HOB) were used as they are a model of the cell type the cements might encounter in vivo. Cell proliferation and growth were assessed by measurement of total cellular DNA and tritiated thymidine ([3H]-TdR) incorporation. Alkaline phosphatase (ALP) production was measured as an indicator of HOB phenotype upon the cements. The results showed that HA/PMMA was a better substrate for HOB cells, resulting in increased proliferation and ALP activity. Scanning e...Continue Reading

Citations

Dec 17, 2014·Journal of Biomedical Materials Research. Part a·Johannes BeckerMahrokh Dadsetan
Jul 2, 2010·Journal of the Royal Society, Interface·K E Tanner
Aug 9, 2002·Tissue Engineering·Matthew J DalbyWilliam Bonfield
Oct 29, 2010·Microscopy Research and Technique·Louise E SmithSheila Macneil
Feb 1, 2012·Journal of Biomaterials Science. Polymer Edition·Zhi-Cai XingInn-Kyu Kang
Dec 4, 2020·Biomolecules·Mayra Eliana Valencia ZapataJosé Herminsul Mina Hernandez
Jan 5, 2002·Biomaterials·M J DalbyL Di Silvio

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