In vitro evaluation of a poly(lactide-co-glycolide)-collagen composite scaffold for bone regeneration

Biomaterials
Sang Jin LeeJames J Yoo

Abstract

Numerous materials have been proposed for bone tissue regeneration. However, none has been shown to be entirely satisfactory. In this study we fabricated a hybrid composite scaffold composed of poly(D,L-lactide-co-glycolide) (PLGA) and a naturally derived collagen matrix derived from porcine bladder submucosa matrix (BSM), and evaluated the biological activities and physical properties of the scaffold for use in bone tissue regeneration. The BSM-PLGA composite scaffolds are able to promote cellular interactions and possess uniformly interconnected pores with adequate structural integrity. The composite scaffolds were tested with both human embryonic stem (hES) cells and bovine osteoblasts (bOB). Cells seeded on the composite scaffolds readily attached, infiltrated and proliferated, as confirmed by cell viability and mitochondrial metabolic activity. Use of the composite scaffolding system with cells may enhance the formation of bone tissue for therapeutic regeneration.

References

Sep 1, 1970·Journal of Biomedical Materials Research·S F HulbertF H Stelling
Nov 6, 1998·Science·J A ThomsonJ M Jones
Sep 17, 1999·Journal of Biomedical Materials Research·K G MarraL E Weiss
May 10, 2002·Journal of Biomedical Materials Research·Shi Hong LiKlaas de Groot
May 23, 2002·Journal of Biomaterials Science. Polymer Edition·Sang Jin LeeHai Bang Lee
Dec 5, 2002·Journal of Biomaterials Science. Polymer Edition·Wanpen TachaboonyakiatMitsuru Akashi
Dec 10, 2003·Journal of Biomaterials Science. Polymer Edition·Daisuke IejimaToshimasa Uemura
Jul 13, 2004·Trends in Biotechnology·Dietmar W HutmacherMakarand V Risbud
Mar 4, 2005·Journal of Materials Science. Materials in Medicine·A J SalgadoR L Reis

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Citations

May 23, 2012·Tissue Engineering. Part C, Methods·Alyssa A AppelEric M Brey
Nov 21, 2008·Biomaterials·Se Heang OhBenjamin S Harrison
Oct 28, 2008·Methods : a Companion to Methods in Enzymology·Daniel EberliJames J Yoo
Aug 31, 2006·Biotechnology Journal·Jan SumerelRoger J Narayan
Aug 14, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Li LiuLe Jin
May 5, 2007·Macromolecular Bioscience·Hyeon Joo KimDavid L Kaplan
Feb 15, 2008·Journal of Tissue Engineering and Regenerative Medicine·M Susana CortizoAna M Cortizo
Feb 4, 2010·Journal of Biomedical Materials Research. Part a·Neda AboudzadehMehdi Farokhi
Feb 1, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Heather DoylePeter McHugh
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Berivan CecenHasan Havitcioglu
Dec 13, 2002·The Journal of Urology·Abdel W El-KassabyAnthony Atala
Oct 27, 2017·Journal of Healthcare Engineering·Somruethai ChannasanonSiriporn Tanodekaew
Apr 5, 2018·Marine Biotechnology·Alisa PalavenieneJolanta Liesiene
Dec 31, 2019·International Journal of Dentistry·Sandra Janeth Gutiérrez-PrietoAdriana P Acosta
Oct 15, 2021·Experimental Biology and Medicine·Shivaani KirankumarJohnson Rajasingh

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