Abstract
The clinical efficacy of allergen-immunotherapy is known to be dose dependent. However, optimal maintenance dosage has not yet been determined for sublingual immunotherapy (SLIT). Furthermore, since companies adopt their own units for expression of allergenicity, the allergen concentrations of individual reagents cannot be compared easily. We sought to measure and compare the allergenicities of 3 commercially available house dust mite (HDM) SLIT regents and a subcutaneous immunotherapy reagent. We measured the HDM allergenic potency of the maintenance dosages of three SLIT reagents: Staloral® (300 index of reactivity [IR] /mL, recommended maintenance dosage [MD]: 120 IR), SLITone® (1,000 standard therapeutic unit [STU]/mL, recommended MD: 200 STU), Wolwopharma® (100 µg/mL, recommended MD: 20 µg), and subcutaneous immunotherapy regents of Hollister-Stier (10,000 allergy unit [AU] /mL). The allergenic potency was assessed by measuring the total protein concentrations, mite group 1 and 2 allergens using 2-site ELISA, and an inhibition test against IgE specific to Dermatophagoides farinae and Dermatophagoides pteronyssinus. The protein content of the Wolwopharma® reagent was 1.5-261.4 times higher than that of the other 2 SLIT reag...Continue Reading
References
Feb 1, 1980·The Journal of Allergy and Clinical Immunology·P S Norman
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J BousquetH J Malling
Mar 17, 2000·The Journal of Allergy and Clinical Immunology·J E Slater, R W Pastor
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W ParkC-S Hong
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Penelope A EwbankHarold S Nelson
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·James N Francis, Stephen R Durham
Mar 2, 2006·International Archives of Allergy and Immunology·Ralph MösgesWalter Lehmacher
Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Stephen R DurhamSabina Rak
Dec 15, 2006·The Journal of Allergy and Clinical Immunology·Ronald van Ree
Oct 6, 2007·The Journal of Allergy and Clinical Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Oct 16, 2007·The Journal of Allergy and Clinical Immunology·Alain DidierMichel Melac
Dec 7, 2007·Allergy·J BousquetH Schünemann
Feb 14, 2008·Allergy·R van ReeB Weber
Mar 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannUNKNOWN Immunotherapy and Allergy Diagnostics Committee of the American Academy of Allergy, Asthma and Immunology
Sep 3, 2008·The Journal of Allergy and Clinical Immunology·Martin D ChapmanUNKNOWN CREATE consortium
Oct 3, 2009·Allergy·E CompalatiG W Canonica
Jan 21, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Linda Cox, Lars Jacobsen
Feb 22, 2011·The Journal of Allergy and Clinical Immunology·Robert K BushWilliam W Busse
Mar 30, 2011·Allergy·S RadulovicStephen Durham
Apr 14, 2011·Yonsei Medical Journal·Kyoung Yong JeongJung-Won Park
Oct 4, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Linda CoxGreg Plunkett
Oct 25, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannDerek Constable
Dec 14, 2011·Allergy·M A CalderónP Demoly
Sep 5, 2013·Allergy, Asthma & Immunology Research·Gyu-Young HurUNKNOWN Allergen and Immunotherapy Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI)
Citations
Feb 15, 2016·Current Allergy and Asthma Reports·Julia ZimmerSusanne Kaul
May 12, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J ZimmerS Kaul
Nov 19, 2017·Allergy·A BonertzS Vieths
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Jul 28, 2016·Allergy·J C Vidal-QuistP Hernández-Crespo
Nov 20, 2019·Ear, Nose, & Throat Journal·Joo Hyun JungSeon Tae Kim
Nov 15, 2017·Allergologia et immunopathologia·Cristina Rivas-JuesasAna M Purroy Tabar