In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery.

Journal of Materials Science. Materials in Medicine
Sumanta Kumar SahuPanchanan Pramanik

Abstract

The development of smart targeted nanoparticle that can deliver drugs to direct cancer cells, introduces better efficacy and lower toxicity for treatment. We report the development and characterizations of pH-sensitive carboxymethyl chitosan modified folic acid nanoparticles and manifest their feasibility as an effective targeted drug delivery vehicle. The nanoparticles have been synthesized from carboxymethyl chitosan with covalently bonded bifunctional 2,2'-(ethylenedioxy)-bis-(ethylamine) (EDBE) through the conjugation with folic acid. The conjugation has been analyzed by Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. The resultant nanoparticles with an average size less then 200 nm measured by dynamic light scattering and transmission electron microscopy. Confocal microscopy and flow cytometric analysis have revealed that folate-mediated targeting significantly enhances the cellular uptake of the nanoparticle and thus facilitates apoptosis of cancer cells (HeLa, B16F1). For the application of the nanoparticles as a drug carrier, Doxorubicin a potent anticancer drug has been loaded into the nanoparticles, with the drug loading amount and the drug release pattern observed.

References

Jan 1, 1986·Annual Review of Biochemistry·I MellmanA Helenius
Mar 1, 1995·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K EnginJ D McFarlane
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R van SluisR J Gillies
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MitraA N Maitra
Dec 26, 2001·Chemical Reviews·K E UhrichK M Shakesheff
Jul 18, 2002·Bioconjugate Chemistry·Emmanuel DautyJean-Paul Behr
Mar 6, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·J H van SteenisW E Hennink
Mar 12, 2003·Advanced Drug Delivery Reviews·Jayanth Panyam, Vinod Labhasetwar
Nov 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·C VauthierP Couvreur
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshiyuki Hattori, Yoshie Maitani
Sep 8, 2004·Advanced Drug Delivery Reviews·Lisa Brannon-Peppas, James O Blanchette
Dec 9, 2004·Chemical Reviews·M N V Ravi KumarA J Domb
Jun 9, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tamara MinkoAlexander V Kabanov
Aug 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Sun ParkYong Woo Cho
Sep 7, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M BreunigA Goepferich
Sep 16, 2008·Journal of Materials Science. Materials in Medicine·Yong YangPing Zhang
Dec 17, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H MaedaJ Daruwalla
Feb 3, 2009·Experimental and Molecular Pathology·Rajesh Singh, James W Lillard
Mar 21, 2009·Bioorganic & Medicinal Chemistry·Amir H Faraji, Peter Wipf

❮ Previous
Next ❯

Citations

Apr 6, 2012·Journal of Materials Science. Materials in Medicine·Saravanabhavan Shanmuga Sundar, Dharmalingam Sangeetha
May 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laxmi UpadhyayaRavi Prakash Tewari
Jun 17, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gozde UnsoyUfuk Gunduz
Feb 16, 2016·International Journal of Pharmaceutics·Shabnam TarvirdipourHassan Bardania
Mar 8, 2016·Progress in Biomaterials·S Esfandiarpour-BoroujeniH Mirzadeh
Apr 14, 2016·Colloids and Surfaces. B, Biointerfaces·Luzhong ZhangYumin Yang
Dec 5, 2013·Carbohydrate Polymers·Maite Arteche PujanaIssa Katime
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Arindam PramanikParimal Karmakar
May 18, 2016·European Journal of Pharmacology·Maryam ParsianUfuk Gunduz
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·Xingzhen ZhangGuangxi Zhai
Nov 5, 2016·Colloids and Surfaces. B, Biointerfaces·Kunal PatelXia Lou
Oct 28, 2016·Journal of Materials Science. Materials in Medicine·Paulo Emilio FeuserPedro H Hermes de Araújo
Sep 16, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Sania NazMuhammad Zia
Aug 15, 2018·Journal of Drug Targeting·Sweet NaskarSuraj Sharma
Apr 4, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Aakanchha JainDharam Veer Kohli
Aug 25, 2017·Drug Development and Industrial Pharmacy·M Gover AntonirajRuckmani Kandasamy
Oct 6, 2020·Macromolecular Bioscience·Anna E CaprificoGianpiero Calabrese
Dec 4, 2019·ACS Omega·Asifkhan ShanavasRohit Srivastava
Jan 20, 2021·ACS Biomaterials Science & Engineering·Na ZhouDemei Yu
Oct 14, 2021·Journal of Biomaterials Science. Polymer Edition·Van Toan NguyenNgoc Quyen Tran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.