In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of some Ebselen analogues

Redox Report : Communications in Free Radical Research
Ange Mouithys-Mickalad MarequeGinette Deby-Dupont

Abstract

Four analogues of Ebselen were synthesized and their glutathione peroxidase activity and antioxidant property evaluated and compared to Ebselen. Among the studied compounds, only diselenide [3] exhibited both glutathione peroxidase activity and radical-scavenging capability. Compounds [3] and [4] showed a strong inhibitory effect (53% and 43%, respectively) on the lipid peroxidation of linoleic acid compared to Ebselen and selenide derivatives ([1] and [2]) which were less active (28%, 26% and 18% inhibition, respectively). A concentration-dependent inhibitory effect was also found in the model of the formation of ABTS*+ radical cation: 65% and 89% inhibition for compound [3] at 10(-4) M and 5 x 10(-5) M, respectively, and 68% and 90% for compound [4], compared to 14% and 52% inhibition for Ebselen and the diselenides [1] and [2] (29%, 46% and 45%, 68%, respectively). By EPR spin trapping technique, the following inhibitory profile of the Ebselen analogues was observed towards the formation of thiyl radicals: Ebselen = [3]>[1]>[2]>[4]. Studies with compound [3] are in progress on oxidative stress cell models.

References

Jan 1, 1984·Methods in Enzymology·M J Green, H A Hill
Jan 1, 1995·Methods in Enzymology·F UrsiniL Flohé
Oct 1, 1995·General Pharmacology·T Schewe
Feb 1, 1997·General Pharmacology·O I Aruoma
Sep 23, 1997·Biochemical and Biophysical Research Communications·J F LiégeoisM Lamy
May 20, 1998·Free Radical Biology & Medicine·N MaulikD K Das
Sep 19, 1998·Free Radical Biology & Medicine·G L Squadrito, W A Pryor
May 16, 2000·Biochemical Pharmacology·A DaiberV Ullrich
Mar 23, 2001·Journal of Medicinal Chemistry·A Mouithys-MickaladJ F Liégeois
Jun 5, 2002·Chemical & Pharmaceutical Bulletin·Toshiyuki KoharaMasafumi Arita
Aug 22, 2002·Redox Report : Communications in Free Radical Research·Antonio CanoMarino B Arnao

❮ Previous
Next ❯

Citations

Jul 18, 2006·Cell Biology and Toxicology·J Saluk-JuszczakR Glowacki
Aug 15, 2013·Bioorganic Chemistry·Joanna SalukBarbara Wachowicz
Jul 19, 2006·Cellular & Molecular Biology Letters·Paweł NowakBarbara Wachowicz
Apr 16, 2019·Physical Chemistry Chemical Physics : PCCP·Barbora TarabováZdenko Machala
Feb 3, 2011·Metallomics : Integrated Biometal Science·Erin E BattinJulia L Brumaghim
Dec 31, 2009·The Journal of Physical Chemistry. a·Gavin S Heverly-Coulson, Russell J Boyd
Sep 15, 2010·The Journal of Physical Chemistry. a·Gavin S Heverly-Coulson, Russell J Boyd
Apr 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amany Tharwat MohammedMohamed M M Metwally

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.