In vitro evaluation of paclitaxel coatings for delivery via drug-coated balloons

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Wiebke KempinAnne Seidlitz

Abstract

Lately, drug-coated balloons have been introduced in interventional cardiology as an approach to treat occluded blood vessel. They were developed for the rapid transfer of antiproliferative drugs during the angioplasty procedure in stenosed vessels with the intent to reduce the risk of restenosis. In this study five different paclitaxel (PTX) balloon coatings were tested in vitro in order to examine how solvents and additives influence coating stability and drug transfer rates. PTX-coated balloons were advanced through a guiding catheter and a simulated coronary artery pathway under perfusion and were then inflated in a hydrogel acceptor compartment. The fractions transferred to the gel, remaining on the balloon and the PTX lost in the simulated coronary pathway were then analysed. The results obtained suggest that the solvent used for the coating process strongly influences the surface structure and the stability of the coating. Ethanol/water and acetone based PTX coatings showed the lowest drug transfer rates to the simulated vessel wall (both <1%) due to their high drug losses during the prior passage through the coronary artery model (more than 95%). Balloons coated with PTX from ethyl acetate-solutions showed smaller drug ...Continue Reading

References

Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew D LevinElazer R Edelman
Nov 15, 2006·The New England Journal of Medicine·Bruno SchellerUlrich Speck
Mar 13, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Bodo CremersBruno Scheller
Sep 15, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Anikó PósaMariann Gyöngyösi
Jan 29, 2011·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Michael Mahmoudi, Ron Waksman
Oct 1, 2011·International Journal of Cardiology·Bernardo Cortese, Alessandra Bertoletti
Nov 2, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Christoph HehrleinUlrich Dietz
Jul 25, 2012·Current Cardiology Reports·Jochen Wöhrle
Oct 23, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Johannes MoesBastiaan Nuijen
Apr 16, 2013·Circulation·Vijaya B KolachalamaElazer R Edelman
May 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Piotr P BuszmanPaweł E Buszman
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Svea PetersenKatrin Sternberg
Jan 7, 2014·PloS One·Anne SeidlitzWerner Weitschies
May 28, 2014·Revista Española De Cardiología·Armando Pérez de PradoFelipe Fernández-Vázquez
Dec 17, 2014·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ricardo O Escárcega, Ron Waksman

❮ Previous
Next ❯

Citations

Jul 31, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Belay Tesfamariam
Aug 25, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gordon Minru XiongYingying Huang
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emily GoelSaami K Yazdani
Aug 15, 2018·Frontiers in Pharmacology·Emily TurnerSaami K Yazdani
Feb 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tingchao ZhangYunbing Wang
Nov 6, 2018·International Journal of Pharmaceutics·Steven E WoolfordSamanthi Wickramasekara
Jun 8, 2021·JACC. Basic to Translational Science·Juan F GranadaGrzegorz L Kaluza
Apr 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Dara AzarVijaya B Kolachalama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.