In vitro Evaluation of Porous borosilicate, borophosphate and phosphate Bioactive Glasses Scaffolds fabricated using Foaming Agent for Bone Regeneration

Scientific Reports
E P ErasmusI Sigalas

Abstract

In this work, glasses within the borosilicate borophosphate and phosphate family were sintered into 3D porous scaffolds using 60 and 70 vol. % NH4(HCO3) as a foaming agent. All scaffolds produced remained amorphous; apart from one third of the glasses which crystallized. All produced scaffolds had porosity >50% and interconnected pores in the range of 250-570 µm; as evidenced by µCT. The in-vitro dissolution of the scaffolds in SBF and changes in compression were assessed as a function of immersion time. The pH of the solution containing the borosilicate scaffolds increased due to the typical non-congruent dissolution of this glass family. Borophosphate and phosphate scaffolds induced a decrease in pH upon dissolution attributed to the congruent dissolution of those materials and the large release of phosphate within the media. As prepared, scaffolds showed compressive strength of 1.29 ± 0.21, 1.56 ± 0.63, 3.63 ± 0.69 MPa for the borosilicate, borophosphate and phosphate samples sintered with 60 vol. % NH4 (HCO3), respectively. Evidence of hydroxyapatite precipitation on the borosilicate glass scaffolds was shown by SEM/EDS, XRD and ICP-OES analysis. The borophosphate scaffolds remained stable upon dissolution. The phosphate sc...Continue Reading

References

Jun 1, 1990·Journal of Biomedical Materials Research·T KokuboT Yamamuro
Jul 1, 1997·Journal of Biomedical Materials Research·M Brink
Nov 9, 2000·Biomaterials·D W Hutmacher
Aug 17, 2005·Biomaterials·Julian R JonesLarry L Hench
Jun 14, 2006·Journal of Materials Science. Materials in Medicine·Wenhai HuangMohamed N Rahaman
Oct 25, 2007·Faraday Discussions·Aldo R BoccacciniJérôme Chevalier
Jun 28, 2008·Acta Biomaterialia·L LefebvreD Bernache-Assolant
Jan 1, 2009·Critical Reviews in Biomedical Engineering·Lijie ZhangKyriacos A Athanasiou
Mar 23, 2011·Acta Biomaterialia·Mohamed N RahamanAntoni P Tomsia
Sep 14, 2011·Materials Science & Engineering. C, Materials for Biological Applications·Qiang FuAntoni P Tomsia
Oct 14, 2011·Journal of the Royal Society, Interface·Yann C FredholmRobert G Hill
Mar 8, 2013·Journal of Biomedical Materials Research. Part a·Gurbinder KaurGary Pickrell
Jan 23, 2014·Tissue Engineering. Part a·Laurent-Emmanuel MonfouletDelphine Logeart-Avramoglou
Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·J MasseraL Hupa
Jun 24, 2015·Journal of Materials Science. Materials in Medicine·J MasseraL Hupa
Dec 24, 2015·Biomedical Materials·R Colquhoun, K E Tanner

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Citations

Jan 20, 2021·ACS Biomaterials Science & Engineering·Maryam Rahmati, Masoud Mozafari

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Methods Mentioned

BETA
X-ray

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