In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations

Pharmaceutics
Lucia MontenegroLorella Pasquinucci

Abstract

The evaluation of UV-filter in vitro percutaneous absorption allows the estimation of the systemic exposure dose (SED) and the margin of safety (MoS) of sunscreen products. As both the vehicle and pattern of application may affect sunscreen safety and efficacy, we evaluated in vitro release and skin permeation of two widely used UV-filters, octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane (BMBM) from topical formulations with different features (oil in water (O/W) emulsions with different viscosity, water in oil (W/O) emulsion, oils with different lipophilicity). To mimic in-use conditions, we carried out experiments repeating sunscreen application on the skin surface for three consecutive days. BMBM release from all these vehicles was very low, thus leading to poor skin permeation. The vehicle composition significantly affected OMC release and skin permeation, and slight increases of OMC permeation were observed after repeated applications. From skin permeation data, SED and MoS values of BMBM and OMC were calculated for all the investigated formulations after a single application and repeated applications. While MoS values of BMBM were always well beyond the accepted safety limit, the safety of sunscreen formulati...Continue Reading

References

Dec 1, 1978·Journal of Pharmaceutical Sciences·M S Roberts, E Harlock
Nov 1, 1986·Journal of Pharmaceutical Sciences·R L BronaughM Simon
Jan 1, 1982·The Journal of Investigative Dermatology·J SwarbrickJ Brom
Jan 1, 1983·Drug Metabolism Reviews·R C Wester, H I Maibach
Sep 1, 1984·Journal of Pharmaceutical Sciences·R L Bronaugh, R F Stewart
Oct 1, 1995·Toxicology Letters·C S OkerekeM S Abdel-Rahman
Oct 1, 1994·Pharmaceutical Research·J HiltonM F Wilks
May 1, 1996·Pharmaceutical Research·P Treffel, B Gabard
Oct 6, 1997·Lancet·C G HaydenH A Benson
Feb 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K A WaltersS D Gettings
Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·L BrinonG Couarraze
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·M Trotta
Jun 16, 2001·Regulatory Toxicology and Pharmacology : RTP·G J Nohynek, H Schaefer
Dec 11, 2002·Clinical and Experimental Dermatology·H Gustavsson GonzalezO Larkö
Feb 5, 2003·Skin Pharmacology and Applied Skin Physiology·E ChatelainC Surber
Dec 1, 1963·Archives of Dermatology·A M KLIGMAN, E CHRISTOPHERS
May 24, 2005·Skin Pharmacology and Physiology·C G J HaydenM S Roberts
May 25, 2006·Drug Development and Industrial Pharmacy·Lucia MontenegroGiovanni Puglisi
Oct 10, 2006·Toxicology and Applied Pharmacology·Petra Y Kunz, Karl Fent
Dec 19, 2006·Journal of Cosmetic Dermatology·Athanasia Varvaresou
May 15, 2007·Toxicology·Tue SøeborgBent Halling-Sørensen
Jul 3, 2007·Toxicology and Applied Pharmacology·Sreeneeranj KasichayanulaXiaochen Gu
Aug 19, 2007·Lancet·Stephan LautenschlagerMark R Pittelkow
Apr 2, 2008·International Journal of Cosmetic Science·L MontenegroG Puglisi
May 3, 2008·International Journal of Cosmetic Science·E B Souto, R H Müller
May 24, 2008·International Journal of Cosmetic Science·E Kurul, S Hekimoğlu
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
Dec 1, 1992·International Journal of Cosmetic Science·A C WatkinsonJ Hadgraft
Jul 28, 2009·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Srei Pisei HuongVéronique Andrieu
Sep 8, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Bram BaertBart De Spiegeleer
Dec 7, 2010·International Journal of Pharmaceutics·L MontenegroG Puglisi
Dec 28, 2012·Journal of the Royal Society, Interface·Emma SparrBernard Cabane
Feb 22, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jarmila HojerováMartina Beránková

❮ Previous
Next ❯

Citations

Aug 28, 2019·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Kirandeep Kaur, Goutam Rath
Apr 21, 2018·Pharmaceutics·Keng Wooi Ng
Nov 3, 2020·International Journal of Pharmaceutics·Rodrigo Collina RomanholePriscila Gava Mazzola

❮ Previous
Next ❯

Software Mentioned

Galaxie

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.