In vitro evaluation of the antimicrobial effect of three endodontic sealers mixed with amoxicillin

Journal of Endodontics
Jeff Baer, James S Maki

Abstract

The purpose of this in vitro study was to evaluate the antimicrobial effect of mixing amoxicillin with three different sealers when freshly mixed and set. Using a direct contact test, Pulp Canal Sealer EWT (SybronEndo Corporation, Orange, CA), AH Plus (Dentsply International Inc, York, PA), and RealSeal SE (Pentron Clinical Technologies LLC, Wallingford, CT) were freshly mixed with amoxicillin and placed on the side wall of the microtiter plate. A 10-microL bacterial suspension of Enterococcus faecalis was placed directly onto the fresh sealers, and sealers set 1 day, 3 days, and 7 days after mixing. The bacteria were allowed to dry in direct contact with the sealer sample. Fresh media was then added, and growth of the bacteria was measured by spectrophotometry over an 8-hour period. One-way analysis of variance (ANOVA), two-way ANOVA, and Tukey multiple comparison were used for statistical significance. All sealers mixed with amoxicillin showed complete inhibition of the growth of E. faecalis. Sealers mixed with amoxicillin had no statistical difference in inhibiting growth between freshly mixed samples and samples set for 1 day, 3 days, or 7 days (p > 0.05). Sealers without amoxicillin did not inhibit growth of E. faecalis, a...Continue Reading

Citations

Aug 13, 2011·Head & Face Medicine·Ines WillershausenBrita Willershausen
Mar 26, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Markus HeyderBernd W Sigusch
Aug 19, 2011·Journal of Endodontics·Christian SengesAli Al-Ahmad
Jan 18, 2017·Journal of Dental Research, Dental Clinics, Dental Prospects·Ali KangarlouOmid Dianat
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Jul 4, 2019·Dentistry Journal·Alexander BrezhnevJukka P Matinlinna
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Sep 26, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaogang ChengXiaohua Liu
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