In vitro evaluation of the bioadhesive properties of hydrophobic polybasic gels containing N,N-dimethylaminoethyl methacrylate-co-methyl methacrylate

Biomaterials
D Quintanar-GuerreroJ M Cornejo-Bravo

Abstract

The bioadhesive properties of the hydrophobic, basic polyelectrolyte hydrogel disks containing crosslinked N,N-dimethylaminoethyl methacrylate-co-methyl methacrylate 30/70mol% were evaluated in vitro using gastric (pH 1.2), sublingual (pH 6.5), vaginal (pH 4.0) and intestinal (pH 7.5) pig's mucosas. Adhesive strength was measured using a modified Du Noüy tensiometer by measuring the force of detachment between a gel disk and the respective mucosa. The effect of crosslinker content in the gel was evaluated. It was found an increase in the adhesive strength with the increase of crosslinker content in the pH range of 4.0-7.5. For the evaluation at pH 1.2 (gastric mucosa) the opposite behavior was observed. The results indicate that initial bioadhesive contact may be the result of surface energy effects and/or electrostatic interactions of oppositely charged groups between mucin and the gel. In some cases, mucus dehydration may also be involved. When the gel is swollen, chain interpenetration also plays a roll in the bioadhesive interaction. The gels presented bioadhesive forces in gastric and vaginal mucosas (acidic medium), similar to the adhesive forces of well-known bioadhesives such as hydroxymethylcellulose and sodium alginat...Continue Reading

References

May 31, 1983·Biochemical and Biophysical Research Communications·A SlomianyL J Newman
Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L S NielsenJ Hansen
Apr 17, 1999·International Journal of Pharmaceutics·C F WongK K Peh
Apr 17, 1999·International Journal of Pharmaceutics·R J SoaneL Illum
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·G P CarinoE Mathiowitz

❮ Previous
Next ❯

Citations

Sep 4, 2013·International Journal of Pharmaceutics·Sabine HauptsteinAndreas Bernkop-Schnürch
Apr 6, 2006·AAPS PharmSciTech·Abeer M Al-GhananeemPeter A Crooks
Jul 16, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sabine HauptsteinAndreas Bernkop-Schnürch
May 6, 2008·Computers in Biology and Medicine·Iosif-Daniel Rosca, Jean-Maurice Vergnaud
Jul 8, 2005·Macromolecular Bioscience·Filippo SaianoGaetano Giammona
Dec 5, 2006·International Journal of Pharmaceutics·G PitarresiF S Palumbo
Jul 14, 2006·International Journal of Biological Macromolecules·Jérôme MulhbacherMircea Alexandru Mateescu
Jul 16, 2005·International Journal of Pharmaceutics·D AmeyeJ P Remon
Aug 20, 2011·Drug Development and Industrial Pharmacy·Valence M K NdesendoLeith C R Meyer
Apr 4, 2015·Carbohydrate Polymers·Sabine HauptsteinAndreas Bernkop-Schnürch
Oct 19, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·José M García PáezJosé L Castillo-Olivares
May 24, 2007·Drug Development and Industrial Pharmacy·Abeer M Al-GhananeemPeter A Crooks
Dec 23, 2004·Journal of Biomaterials Applications·J M García PaézJ L Castillo-Olivares
Feb 12, 2004·Journal of Biomaterials Applications·J M García PáezA Cordon
Mar 1, 2006·AAPS PharmSciTech·Abeer M Al-GhananeemPeter A Crooks
Jan 10, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Pascal BretonPatrick Couvreur
European Journal of Drug Metabolism and Pharmacokinetics
I D Rosca, J M Vergnaud
© 2021 Meta ULC. All rights reserved