In vitro evaluation of traditionally used Surinamese medicinal plants for their potential anti-leishmanial efficacy

Journal of Ethnopharmacology
D R A MansH D F H Schallig

Abstract

Plant-based preparations are extensively used in Surinamese folk medicine for treating leishmaniasis, but often without a scientific rationale. To evaluate 25 Surinamese medicinal plants for their potential efficacy against leishmaniasis. Concentrated plant extracts were evaluated for their effect on the viability of L. (V.) guyanensis AMC, L. (L.) major NADIM5, and L. (L.) donovani GEDII promastigotes, as well as intracellular amastigotes of L. (L.) donovani BHU814 in infected THP-1 cells. Selectivity was assessed by cytotoxicity against THP-1 cells. The only plant extract that showed potentially meaningful anti-leishmanial activity was that from Solanum lycocarpum that displayed mean IC50 values of about 51, 61, and <16 µg/mL against L. (V) guyanensis, L. (L) major, and L. (L) donovani promastigotes, respectively; about 374 µg/mL against L. (L) donovani amastigotes; and >500 µg/mL against THP-1 cells. The Bryophyllum pinnatum, Inga alba, and Quassia amara extracts displayed moderate to high IC50 values against promastigotes (about 51 to >500 µg/mL) and/or amastigotes (about 224 to >500 µg/mL) but were relatively toxic to THP-1 cells (IC50 values <16 to about 42 µg/mL). The remaining plant extracts exhibited in many cases IC50...Continue Reading

References

Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
May 1, 1996·Revista Da Sociedade Brasileira De Medicina Tropical·F FrançaP D Marsden
Dec 1, 1995·Acta Tropica·S A Da SilvaB Rossi-Bergmann
Jul 16, 1999·Parasitology·S A Da-SilvaB Rossi-Bergmann
Feb 1, 2002·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·M M Weigel, R X Armijos
Feb 28, 2002·Current Pharmaceutical Design·M A Vannier-SantosW de Souza
Nov 28, 2002·International Journal of Dermatology·Esther J S K Lai A FatRudy F M Lai A Fat
Aug 14, 2003·Phytotherapy Research : PTR·E C Torres-SantosB Rossi-Bergmann
Jul 1, 2004·Comparative Immunology, Microbiology and Infectious Diseases·P Desjeux
Jan 11, 2005·Current Medicinal Chemistry·Z GuoR D Sindelar
Jan 19, 2006·Clinical Microbiology Reviews·Simon L CroftAlan H Fairlamb
Feb 2, 2006·Planta medica·Michelle F MuzitanoSônia S Costa
Jan 20, 2007·Journal of Ethnopharmacology·Fernanda G BragaElaine S Coimbra
Mar 14, 2007·Clinics in Dermatology·Mark S Bailey, Diana N J Lockwood
Aug 24, 2007·The Lancet Infectious Diseases·Richard ReithingerSimon Brooker
Sep 25, 2007·Journal of Ethnopharmacology·Y EstevezM Sauvain
Apr 29, 2008·Emerging Infectious Diseases·Wendy van der MeideLeslie Sabajo
Mar 27, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Denise C ArrudaSilvia R B Uliana
Jan 13, 2010·Journal of Ethnopharmacology·María Salomé GachetWolfgang Schühly
Mar 30, 2010·The American Journal of Tropical Medicine and Hygiene·Pieter-Paul A M van ThielAldert Bart
Aug 17, 2010·Journal of Ethnobiology and Ethnomedicine·Gaia LuziatelliPer Mølgaard
Apr 24, 2012·Veterinary Parasitology·Marina Parissi AcciolyRoselaine P A Cardoso
Apr 25, 2012·ISRN Pharmacology·Marley GarcíaPedro Herrera
May 5, 2012·The American Journal of Tropical Medicine and Hygiene·Ricardo V P F HuRudy F M Lai A Fat
May 9, 2012·Journal of Analytical Methods in Chemistry·Renata Fabiane Jorge TiossiJairo Kenupp Bastos
Aug 25, 2012·TheScientificWorldJournal·Laura C LaurellaValeria P Sülsen
Dec 5, 2012·Parasites & Vectors·Anna Dostálová, Petr Volf
Aug 1, 2007·Expert Opinion on Drug Discovery·Ilias Muhammad, Volodymyr Samoylenko
Apr 12, 2013·Chemistry & Biodiversity·Mariza Abreu MirandaJairo Kenupp Bastos
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Valdir Cechinel FilhoAngela Malheiros
May 23, 2014·Experimental Parasitology·Tatiana G RibeiroRachel O Castilho

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Citations

Sep 2, 2016·Journal of Medicinal Food·Sandra Maria BarbalhoRicardo de Alvares Goulart

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