In vitro evaluation of virulence attributes of Candida spp. isolated from patients affected by diabetes mellitus

Oral Microbiology and Immunology
M ManfrediS R Porter

Abstract

Diabetes mellitus is a common disease found worldwide and it has been previously suggested that oral candidal infections may be more frequent or severe in patients with this disease. Systemic and local factors may influence the balance between the host and yeasts, and favour the transformation of Candida isolates from commensal to pathogenic microorganisms. Candida species have developed specific virulence mechanisms that confer the ability to colonise host surfaces, to invade deeper host tissue, or to evade host defences. Few studies have investigated the expression of the virulence attributes of oral Candida isolates in patients with diabetes mellitus. The in vitro extracellular proteinase production and the in vitro ability to adhere to fibronectin of 229 Candida isolates of two geographic different groups of patients with diabetes mellitus and of healthy subjects were assessed. Candida isolates of patients with diabetes mellitus expressed a higher ability to adhere than those of healthy subjects. Higher levels of adhesion were also recorded in patients with a lower oral Candida colonisation. No differences were observed in the in vitro expression of extracellular proteinase of Candida isolates of patients with diabetes mell...Continue Reading

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Citations

Jun 25, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Edna Aparecida Ferraz de Araújo NavasCristiane Yumi Koga-Ito
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Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Madeleine Souza das ChagasGloria Fernanda Castro
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Maristela Barbosa PortelaGloria Fernanda Barbosa de Araújo Castro
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Oct 2, 2007·Mycopathologia·Regina Helena Pires-GonçalvesMaria José Soares Mendes-Giannini
Oct 16, 2020·Microbial Pathogenesis·Manoel Francisco Rodrigues NettoMarcelo Fabiano Gomes Boriollo

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