PMID: 3900613Oct 7, 1985

In vitro evidence for a blood-borne renin-releasing factor

Life Sciences
J H UrbanM S Brownfield

Abstract

The present studies using kidney slices were designed to test whether serotonergic stimulation of renin secretion is mediated via an endocrine signal. Previous in vivo studies have indicated that central serotonergic neurons regulate renin secretion. Administration of the serotonin releaser dl-p-chloroamphetamine-HCl (PCA) to rats causes dose-dependent increases in renin secretion that can be blocked by serotonin depletion with p-chlorophenylalanine (PCPA), injections of 5,7-dihydroxytryptamine into the dorsal raphe nucleus or ablation of the mediobasal hypothalamus. The renin-releasing substance was obtained from nephrectomized male donor rats which were sacrificed 1 hour after receiving an injection of PCA intraperitoneally. Plasma from rats that received saline injections was used as control. The plasma was collected and separated by ultrafiltration into fractions containing solutes with molecular weights between 500-10,000 daltons. The renin-releasing ability of this substance was studied in vitro using rat renal cortical slices. The plasma fraction (M.W. = 500 - 10,000) from rats treated with PCA caused dose-dependent increases in renin release from the kidney slices. Heating of the plasma factor at 100 degrees C for 30 mi...Continue Reading

References

Jun 1, 1986·Journal of Pharmacological Methods·J H Urban, L D van de Kar
Jan 1, 1996·Behavioural Brain Research·L D van de KarA D Levy
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·L D van de Kar
Jan 10, 2001·Canadian Journal of Physiology and Pharmacology·V ContesseH Vaudry
Jan 12, 1999·Frontiers in Neuroendocrinology·L D van de Kar, M L Blair
Mar 29, 2011·Journal of Bacteriology·Marie-Pierre DubeauRyszard Brzezinski

Citations

Jan 1, 1978·Annual Review of Physiology·I A ReidW F Ganong
Jun 12, 1978·Annals of the New York Academy of Sciences·E Sanders-Bush, L R Steranka
Apr 1, 1979·The Journal of Clinical Endocrinology and Metabolism·R S ModlingerS P Arora
Sep 1, 1978·Endocrinology·H R PowellE Rotenberg
Feb 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·C PolomskiF M Bumpus
Jun 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·J H Hauger-KleveneN Fleischer
Oct 8, 1984·Brain Research·L D van de KarC L Bethea
Aug 1, 1980·Neuroendocrinology·R W Fuller, H D Snoddy

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