In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow

Journal of Neurointerventional Surgery
Frank LallyChristine Roffe

Abstract

Mechanical thrombectomy with stent retriever devices is associated with significantly better outcomes than thrombolysis alone in the treatment of acute ischemic stroke. Thrombus aspiration achieves high patency rates, but clinical outcomes are variable. The aim of this study was to examine the effect of different suction conditions on perfusate flow during aspiration thrombectomy. A computational fluid dynamics model of an aspiration device within a patent and occluded blood vessel was used to simulate flow characteristics using fluid flow solver software. A physical particulate flow model of a patent vessel and a vessel occluded by thrombus was then used to visualize flow direction and measure flow rates with the aspiration catheter placed 1-10 mm proximal of the thrombus, and recorded on video. The mathematical model predicted that, in a patent vessel, perfusate is drawn from upstream of the catheter tip while, in an occluded system, perfusate is drawn from the vessel proximal to the device tip with no traction on the occlusion distal of the tip. The in vitro experiments confirmed the predictions of this model. In the occluded vessel aspiration had no effect on the thrombus unless the tip of the catheter was in direct contact...Continue Reading

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Citations

Jul 6, 2019·Journal of Neurointerventional Surgery·Kurt YaegerJohanna T Fifi
Jun 15, 2019·Journal of Neurointerventional Surgery·Sonia SanchezMarc Ribo
Oct 13, 2018·AJNR. American Journal of Neuroradiology·O NikoubashmanM Wiesmann
Nov 4, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sanjeev Nayak
Apr 17, 2021·Journal of Neurointerventional Surgery·Jiahui LiMarc Ribo
Dec 24, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Raul G NogueiraDiogo C Haussen
Aug 28, 2021·Journal of Biomechanics·Giulia LuraghiAli C Akyildiz
Apr 2, 2020·Interventional Neurology·Asim RizviDavid F Kallmes

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