PMID: 20650071Apr 1, 1995Paper

In vitro exposure of rabbit tracheal epithelium to SO(2): Effects on morphology and ciliary beating

Toxicology in Vitro : an International Journal Published in Association with BIBRA
C BlanquartF Marano

Abstract

The aim of this in vitro study was to characterize the direct effects of short-term exposure to low concentrations of sulfur dioxide (SO(2)) on both the morphology and the physiology of rabbit tracheal primary cultures. Scanning electron microscopy (SEM) studies revealed that ciliated cells exposed for 1 hr to 10 ppm or 30 ppm SO(2) exhibited aggregated cilia. Transmission electron microscopy revealed numerous swollen mitochondria in cells exposed to 30 ppm SO(2) for 1 hr. This morphological damage to cells was coupled with physiological alterations. A 25% decrease in ciliary beat frequency (CBF) was measured in cells exposed to 30 ppm SO(2). This inhibition was partially reversible within 24 hr. This SO(2) concentration also induced a significant depletion of cellular ATP content which was completely restored after a 24-hr recovery period. A correlation was found between cellular ATP level depletion and CBF decrease.

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Citations

May 17, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F LestariB Markovic
Jun 6, 2000·Advanced Drug Delivery Reviews·F W MerkusE Marttin
Apr 20, 2011·Clinical and Experimental Pharmacology & Physiology·Rong-Yuan ZhangHong-Fang Jin
Mar 17, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guohua QinNan Sang
Sep 10, 2005·Toxicology and Industrial Health·S BakandB Markovic
Feb 2, 2010·Journal of Pharmacological and Toxicological Methods·Shahnaz Bakand, Amanda Hayes

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