In vitro extracellular and intracellular activity of two newer and two earlier fluoroquinolones against Listeria monocytogenes

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
B FacinelliP E Varaldo

Abstract

Two new fluoroquinolones (trovafloxacin and sparfloxacin) with enhanced activity against gram-positive pathogens and two earlier compounds (ciprofloxacin and ofloxacin) were tested for their in vitro inhibitory and bactericidal activity against 80 strains of Listeria monocytogenes. All strains were uniformly highly susceptible to trovafloxacin, the MIC90 being 0.25 mg/l. Resistance to sparfloxacin was not detected, however the MIC90 of sparfloxacin was eight times that of trovafloxacin. A few strains were resistant to ciprofloxacin and ofloxacin (MIC90 4 mg/l for both drugs). MBCs usually exceeded MICs by 2 to 4 times. The MBC90 of trovafloxacin (1 mg/l) was lower than that of the other three drugs (8 mg/l). After checking their ability to enter and grow within human enterocyte-like Caco-2 cells, four strains were used to study the intracellular activity and eradicating power of the four quinolones. Trovafloxacin was more active than sparfloxacin and the earlier fluoroquinolones in terms of both intracellular killing and inhibition of a cytopathogenic effect. The uniform high-level activity of trovafloxacin against Listeria monocytogenes isolates in conventional in vitro assays and its extracellular and intracellular killing of...Continue Reading

References

Nov 16, 1991·Lancet·B FacinelliU Fabio
Apr 1, 1991·Clinical Microbiology Reviews·A SchuchatC V Broome
Jul 1, 1991·Diagnostic Microbiology and Infectious Disease·M D ApplemanC W Stratton
Mar 1, 1991·Antimicrobial Agents and Chemotherapy·N X ChinH C Neu
Sep 16, 1989·BMJ : British Medical Journal·B FacinelliU Fabio
Nov 1, 1989·Antimicrobial Agents and Chemotherapy·T KojimaS Mitsuhashi
Mar 1, 1989·Reviews of Infectious Diseases·P J van den Broek
Aug 1, 1989·Antimicrobial Agents and Chemotherapy·S NakamuraT Ohue
Nov 1, 1987·Journal of Clinical Microbiology·L PineG B Malcolm
Mar 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E M Jones, A P MacGowan
Apr 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C BurucoaR Robert
Jul 1, 1995·The Journal of Infectious Diseases·E CharpentierP Courvalin
Nov 1, 1994·Antimicrobial Agents and Chemotherapy·H C Neu, N X Chin
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·B B Gooding, R N Jones
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·L J Piddock
Mar 1, 1994·Antimicrobial Agents and Chemotherapy·C MicheletP Berche
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering
Jan 1, 1996·Applied and Environmental Microbiology·M C RobertsP E Varaldo
Mar 21, 1996·The New England Journal of Medicine·F S Southwick, D L Purich
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B Lorber
Feb 1, 1997·The Journal of Antimicrobial Chemotherapy·A PascualE J Perea
Apr 1, 1997·Clinical Microbiology Reviews·H HofM Kretschmar
Feb 1, 1996·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Roger Cluzel

❮ Previous
Next ❯

Citations

Aug 1, 2002·Current Gastroenterology Reports·Nancy F Crum
Oct 3, 2003·Diagnostic Microbiology and Infectious Disease·G A RiveroD P Kontoyiannis
Aug 2, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James A KarlowskyGeorge G Zhanel
Feb 11, 1999·The Annals of Pharmacotherapy·A A Alghasham, M C Nahata
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·C MicheletM G Täuber
Jun 14, 2000·The Annals of Pharmacotherapy·M E Temple, M C Nahata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.