PMID: 8580653Oct 1, 1995Paper

In vitro fertilization in women age 40 and older: the impact of assisted hatching

Journal of Assisted Reproduction and Genetics
W B SchoolcraftH W Jones

Abstract

To assess the impact of assisted hatching on in vitro fertilization (IVF) outcome in women age 40 and older. A retrospective analysis was performed to compare 28 cycles of IVF without assisted hatching to 38 cycles of IVF with assisted hatching. All patients in both groups were age 40 or older and the mean age was similar. The delivery rate per oocyte retrieval was significantly higher in the assisted hatching group (18/38; 48%) compared to the nonhatched controls (3/28; 11%, P = 0.0003). The implantation rate of hatched embryos (40/175; 22%) was clearly enhanced, compared to the nonhatched embryos (7/126; 6%, P < 0.001). The fertilization rate, number of oocytes and the number of embryos per patient were comparable in the two groups. Assisted hatching dramatically improves embryonic implantation and term pregnancy rates in women age 40 and older undergoing IVF.

Citations

Oct 26, 2005·Journal of Assisted Reproduction and Genetics·Tiffany L RhodesWilliam R Boone
May 15, 2010·Journal of Assisted Reproduction and Genetics·Pelin KutluOmer Faruk Vanlioglu
Nov 3, 2010·Journal of Assisted Reproduction and Genetics·Mohamad Eid HammadehKhaled Refaat Ali
May 13, 2003·Bulletin of Medical Ethics·Emma Wray, Giovanni Incorvati
Mar 21, 2013·Reproductive Biology and Endocrinology : RB&E·Chanchai ChailertTeraporn Vutyavanich
Feb 19, 2011·Human Fertility : Journal of the British Fertility Society·Gerasimos Marinakis, Dimitrios Nikolaou
Feb 2, 2010·Reproductive Biomedicine Online·Mojtaba Rezazadeh ValojerdiBahar Movaghar
Oct 17, 2003·Endocrinology and Metabolism Clinics of North America·Lubna Pal, Nanette Santoro
May 29, 2001·Journal of Biomedical Optics·D H Douglas-Hamilton, J Conia
Aug 29, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Lulu A al-Nuaim, Julian M Jenkins

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