PMID: 9421972Jan 9, 1998Paper

In vitro fluence rate effects in photodynamic reactions with AIPcS4 as sensitizer

Photochemistry and Photobiology
A C MoorJ VanSteveninck

Abstract

It has been shown previously that the efficiency of photodynamic therapy (PDT) both in vivo and in vitro is dependent on fluence rate. In this study, different in vitro experiments showed that tetrasulfonated aluminum phthalocyanine (AIPcS4) is more efficient in photosensitization if the light is delivered at low fluence rate. Erythrocyte damage, virus inactivation and photooxidation of reduced glutathione (GSH) and histidine were all enhanced if light was delivered at 100 W/m2 as compared to 500 W/m2. Bleaching did not occur under these conditions. Oxygen depletion, shown to be important in fluence rate effects observed in vivo, does not seem to be involved. On theoretical grounds saturation of the triplet state is not likely under these conditions. A possible explantation for the observed fluence rate effects might be found in different reaction pathways, that are favored under high or low fluence rate illuminations. These reactions might involve uni- or bimolecular reactions of intermediate products, resulting in less efficiency at higher fluence rate. It proves to be important, under all circumstances, to monitor fluence rate, because a change in fluence rate, even with similar total fluences, might influence photobiologica...Continue Reading

References

Aug 1, 1976·Acta Physiologica Scandinavica·A Carlsen, J O Wieth
Jun 1, 1991·Radiation Research·T H FosterR Hilf
Dec 1, 1987·Journal of Photochemistry and Photobiology. B, Biology·A Andreoni
Dec 1, 1988·Journal of Photochemistry and Photobiology. B, Biology·F RicchelliL Lindqvist
Mar 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E Ben-HurI Rosenthal
Dec 1, 1973·The Journal of General Physiology·P Naccache, R I Sha'afi
Apr 1, 1969·Genetical Research·W G Hill
Feb 1, 1996·Photochemistry and Photobiology·C R LambertI E Kochevar
Nov 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R B Veenhuizen, F A Stewart
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Apr 1, 1963·The Journal of Clinical Investigation·R I WEEDG BERG

❮ Previous
Next ❯

Citations

Oct 26, 2005·The Journal of Membrane Biology·G Stark
Jun 9, 2000·Journal of the American Veterinary Medical Association·M D LucroyB R Madewell
Mar 8, 2013·Photodiagnosis and Photodynamic Therapy·Mathias O Senge, Marek W Radomski
Jan 5, 2006·Lasers in Surgery and Medicine·Steen J MadsenHenry Hirschberg
Jan 1, 2005·The Journal of Membrane Biology·F KilligH J Apell
Aug 10, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Arno WieheMathias O Senge
Feb 8, 2000·Physics in Medicine and Biology·T Schunck, P Poulet
Nov 26, 2013·Photochemistry and Photobiology·Min YaoIrene E Kochevar
Apr 25, 2021·Photodiagnosis and Photodynamic Therapy·Maha FadelSarah Salah Thabet
Jan 12, 2001·Journal of Photochemistry and Photobiology. B, Biology·K OrthA Rück
Jun 6, 2000·Advanced Drug Delivery Reviews·O V GerasimovD H Thompson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.