In vitro fructose exposure overactivates NADPH oxidase and causes oxidative stress in the isolated rat aorta

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Camila Almenara C PereiraAlessandra Simão Padilha

Abstract

Fructose acutely interferes with cardiovascular function in humans and in animals, but the mechanisms remain unclear. Thus, we tested whether fructose can affect endothelial function without the interference of its metabolic effect by exposing the rat aorta to a high fructose concentration and then evaluate the vascular responses to vasoactive agents. We observed that fructose exposure causes overactivation of NADPH oxidase, which enhances superoxide anion production and increases NO degradation. Additionally, the enhanced vasoconstrictor action of hydrogen peroxide might exacerbate contractile responses. This vasoactive imbalance might be the key role by which fructose induces vascular dysfunction.

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Citations

May 18, 2017·Nutrition Research Reviews·Eva GatineauLaurent Mosoni
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Aug 18, 2020·Life Sciences·Deborah de Farias LelisMarcelo Perim Baldo

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