PMID: 153786Jan 1, 1979Paper

In vitro functional studies of mononuclear cells in patients with CLL: evidence for functionally normal T lymphocytes and monocytes and abnormal B lymphocytes

Cancer
T Han, B Dadey

Abstract

In vitro functional studies of mononuclear cells from 34 patients with B-cell type CLL were investigated and the results of these studies were as follows: 1) The T lymphocytes from patients with CLL were capable of responding normally to PHA or PWM, of inducing allogeneic normal B lymphocytes to respond to these mitogens and of stimulating normally to allogeneic lymphocytes in "one-way" mixed lymphocyte reaction; 2) The monocytes from these patients were capable of enhancing the T lymphocyte response to mitogens and of stimulating normally to allogeneic lymphocytes; and 3) The leukemic B lymphocytes were incapable of responding to mitogens even in the presence of normal T lymphocytes and their enhancer cell activity on T lymphocyte response or their stimulating capacity on allogeneic lymphocytes was depressed. These observations suggest that the T lymphocytes and monocytes from patients with CLL are functionally normal while the leukemic B lymphocytes from these patients are functionally abnormal.

References

Sep 1, 1977·Journal of the National Cancer Institute·T TsubotaD Pressman
Jan 1, 1976·Journal of Immunological Methods·T Han, J Minowada
Sep 1, 1976·Cell and Tissue Kinetics·B JaksićL Pegoraro
Jan 20, 1973·Lancet·J WybranH H Fudenberg
Feb 21, 1973·Nature: New Biology·B Phillips, I M Roitt
Oct 1, 1972·The American Journal of Medicine·T HanG E Moore
Jul 1, 1974·The Journal of Experimental Medicine·M GreavesM Doenhoff
Mar 1, 1960·Experimental Cell Research·P Nowell

Citations

Jul 1, 1982·Journal of Clinical Immunology·P GuglielmiM Seligmann
Jun 1, 1982·Cancer Genetics and Cytogenetics·G Gahrton, K H Robèrt
Aug 23, 1979·The New England Journal of Medicine·G GahrtonA G Bird
Jan 1, 1983·Journal of Clinical Pathology·S CortellazzoN Semeraro
Mar 1, 1981·The Journal of Clinical Investigation·H OzerD Sheedy
Jan 1, 1991·Leukemia Research·P G BriggsR C Atkins
Jan 1, 1990·Leukemia Research·P G BriggsR C Atkins
Feb 1, 1981·Clinical Immunology and Immunopathology·L A FernandezG R Langley
Jan 1, 1981·American Journal of Hematology·M B Van Scoy-MosherR A Gatti
Sep 1, 1987·International Journal of Cell Cloning·Y C Dai, J F Prchal
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·T L GerrardA M Kaplan
May 1, 1986·American Journal of Hematology·R T Perri, N E Kay
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·C S Witt, M P Alpers
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J GilbreathP Phisphumvithi
Apr 16, 2003·Parasite Immunology·Kåre KempLars Hviid
Oct 1, 1992·Immunology and Cell Biology·W H WardF W Eaves
Mar 1, 1983·Journal of Dairy Science·H Ishikawa, T Shimizu
Oct 1, 1986·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·H KoyamaH Saito
Mar 1, 1990·Zentralblatt für Veterinärmedizin. Reihe A·K KadotaN Hashimoto

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