PMID: 11931027Apr 5, 2002Paper

In vitro generation of organophosphate resistant boophilus microplus (Acari: Ixodidae) cell lines

Journal of Medical Entomology
Raquel Cossio-BayugarPatricia J Holman

Abstract

Three organophosphate resistant Boophilus microplus Canestrini cell lines were generated by exposing B. microplus VIII-SCC cell line to incrementally increased toxic concentrations of the acaricide coumaphos. The development of resistance was evidenced by LC50 values elevated over those of control cells. The resistant cell lines selected in higher concentrations of organophosphate, designated C44 and C54, also had significantly slower duplication rates than a resistant cell line selected in lower concentrations of coumaphos (C34) and the nonresistant control cells. Resistant cell lines C44 and C54 also had significantly higher levels of esterase after exposure to coumaphos than resistant cell line C34 and the nonresistant controls. These in vitro results agree with reports of increased esterase activity associated with organophosphate resistance in B. microplus ticks in vivo.

References

Jun 20, 1977·Journal of Medical Entomology·O H Graham, J L Hourrigan
Jun 1, 1992·Trends in Pharmacological Sciences·T Narahashi
Apr 1, 1988·Journal of Economic Entomology·R L HarrisH O Bazan
Apr 1, 1973·Australian Veterinary Journal·C O KnowlesH J Schnitzerling
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M Simon, M Schindler
Oct 1, 1996·Current Opinion in Genetics & Development·M M GottesmanS V Ambudkar
Nov 5, 1997·Biochemical and Biophysical Research Communications·J Y ChangL Z Liu

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Citations

Jul 31, 2007·Trends in Parasitology·Lesley Bell-SakyiFrans Jongejan
Apr 15, 2008·Insect Biochemistry and Molecular Biology·Eliane EstevesSirlei Daffre
Nov 18, 2005·Insect Biochemistry and Molecular Biology·Raquel Cossío-BayúgarPatricia J Holman
Mar 2, 2006·Journal of Medical Entomology·Felix D GuerreroPeter Willadsen
Mar 12, 2020·Frontiers in Physiology·Ahmed Al-Rofaai, Lesley Bell-Sakyi
Jul 8, 2021·Ticks and Tick-borne Diseases·Leidiane Lima-DuarteDarci Moraes Barros-Battesti

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