In vitro gentamicin release from commercially available calcium-phosphate bone substitutes influence of carrier type on duration of the release profile

BMC Musculoskeletal Disorders
Hein P StallmannPaul I J M Wuisman

Abstract

Polymethyl-methacrylate (PMMA) beads releasing antibiotics are used extensively to treat osteomyelitis, but require surgical removal afterwards because they do not degrade. As an alternative option, this report compares the in vitro gentamicin release profile from clinically used, biodegradable carrier-materials: six injectable cements and six granule-types. Cement cylinders and coated granules containing 3% gentamicin were submerged in dH2O and placed in a 48-sample parallel drug-release system. At regular intervals (30, 90, 180 min. and then every 24 h, for 21 days), the release fluid was exchanged and the gentamicin concentration was measured. The activity of released gentamicin was tested on Staphylococcus aureus. All combinations showed initial burst-release of active gentamicin, two cements had continuous-release (17 days). The relative release of all cements (36-85%) and granules (30-62%) was higher than previously reported for injectable PMMA-cements (up to 17%) and comparable to other biodegradable carriers. From the cements residual gentamicin could be extracted, whereas the granules released all gentamicin that had adhered to the surface. The high release achieved shows great promise for clinical application of these...Continue Reading

References

Dec 1, 1989·Acta Orthopaedica Scandinavica·G Walenkamp
May 1, 1997·Journal of Pharmaceutical Sciences·M BohnerB Gander
Apr 15, 1999·Nature Medicine·H van de BeltH J Busscher
Jan 27, 2000·The Journal of Trauma·T J BlokhuisH J Haarman
Jul 8, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·I Soriano, C Evora
Oct 18, 2000·Journal of Biomedical Materials Research·M W NijhofA J Verbout
Jan 6, 2001·Acta Orthopaedica Scandinavica·H van de BeltH J Busscher
Apr 9, 2001·International Journal of Pharmaceutics·S TorradoG Frutos
Jun 5, 2001·The Journal of Antimicrobial Chemotherapy·D NeutH J Busscher
Jun 22, 2001·The Journal of Antimicrobial Chemotherapy·T A WichelhausV Brade
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl L NelsonKeith M Olsen
Oct 22, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·M BaroC Evora
Dec 11, 2002·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Johannes G E HendriksHenk J Busscher
Apr 30, 2003·The Journal of Antimicrobial Chemotherapy·C FaberP I J M Wuisman
Sep 11, 2003·Clinical Orthopaedics and Related Research·George CiernyJohan J Penninck
Jul 3, 2004·The Journal of Antimicrobial Chemotherapy·Hein P StallmannPaul I J M Wuisman
May 10, 2005·Biomaterials·C FaberUNKNOWN Skeletal Tissue Engineering Group Amsterdam
Nov 3, 2005·Current Neurology and Neuroscience Reports·Howard S Kirshner

❮ Previous
Next ❯

Citations

May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Wen-Yu SuFeng-Huei Lin
Jan 8, 2013·Expert Opinion on Drug Delivery·Otto S KluinDaniëlle Neut
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Claudia FloresNicolas Blanchemain
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Colm McManamonGraham L W Cross
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Gemma MestresCecilia Persson
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Shou-Cang ShenReginald Beng Hee Tan
Nov 12, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vera LuginbuehlKatja Nuss
Dec 22, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Peih-Jeng JiangLiam M Grover
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Anna Morawska-ChochółPrzemysław Mielczarek
Sep 17, 2009·The Annals of Pharmacotherapy·Patricia I SealyJohn D Cleary
Sep 20, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Matt E BrownDavid A Puleo
Jul 10, 2018·The Journal of the American Academy of Orthopaedic Surgeons·Pierre-Sylvain MarcheixFranck Sturtz
Aug 30, 2008·Journal of Biomaterials Science. Polymer Edition·W J E M HabrakenJ A Jansen
Nov 1, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hein P StallmannPaul I J M Wuisman
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·W J E M HabrakenJ A Jansen
Jul 8, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wouter J E M HabrakenJohn A Jansen
Jul 26, 2011·Journal of Materials Science. Materials in Medicine·Shou-Cang ShenReginald Beng Hee Tan
Feb 27, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Brian AllenKen Gall
Oct 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zachary JonesKristofer D Sinclair

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.