In Vitro Human Microbiota Response to Exposure to Silver Nanoparticles Biosynthesized with Mushroom Extract

Nutrients
Emanuel VamanuIonela Sârbu

Abstract

The ability to orally administer silver nanoparticles (AgNPs) in enteric capsules implies a direct interaction with the colon microbiota. The in vitro effect provides a portrayal of the functional properties under in vivo conditions. The purpose of this study was to describe a green AgNP synthesis process, using aqueous extract from Lactarius piperatus mushroom, and to characterize the nanomaterial. We determined its antimicrobial and antioxidant effects in vitro in the microbiota of healthy individuals via the GIS1 system-a colon transit simulator. Per the quantitative polymerase chain reaction (qPCR) results, the antimicrobial properties of the AgNPs affected the initial share of different enteric species by decreasing the Bacteroides, Enterobacteriaceae, and Lactobacillus populations and favoring the Bifidobacterium group. The association between AgNPs and wild mushroom L. piperatus extract had a synergistic antibacterial activity against various pathogenic microorganisms while the mushroom extract reduced biofilm formation. Administration of AgNP maintained its constant antioxidant status, and it was correlated with a reduction in ammonium compounds. The physicochemical characterization of these NPs complemented their bioch...Continue Reading

References

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Nov 30, 2016·Journal of Medicinal Food·Emanuel VamanuIonela Sarbu

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Citations

Jan 11, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Yuqiang BiMuriel Mercier-Bonin
Aug 5, 2020·Materials·Zhanar KubashevaBogusław Buszewski
Sep 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Garima SharmaSang-Soo Lee
Jan 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ashiqur RahmanClayton Jeffryes
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anam AhsanAmna Parveen
Mar 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ashiqur RahmanClayton Jeffryes
Aug 23, 2020·Cancers·Siang-Siang ChewLearn-Han Lee
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga TsivilevaAnastasiya Ivanova
Jun 27, 2020·Current Pharmaceutical Design·Abimanyu Sugumaran, Vishali Mathialagan
May 10, 2020·Chemical Research in Toxicology·Angela A M KämpferRoel P F Schins

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Methods Mentioned

BETA
Atomic
Scanning Electron Microscopy
Assay
AFM

Software Mentioned

GraphPad Prism
GraphPad
Excel

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