In vitro human skin penetration model for organophosphorus compounds with different physicochemical properties

Toxicology in Vitro : an International Journal Published in Association with BIBRA
L ThorsA Bucht

Abstract

A flow-through diffusion cell was validated for in vitro human epidermal penetration studies of organophosphorus compounds (OPCs) applied by infinite dosing. By testing OPCs with similar molecular weight but different physicochemical properties, it was shown that hydrophilic and lipophilic properties are major determinants for the penetration rate. Lipophilic OPCs displayed maximum cumulative penetration in the 20-75% agent concentration range whereas the hydrophilic OPCs displayed maximum cumulative penetration at 10 or 20% agent concentration. Low penetration was observed for all agents at 1% agent concentration or when applied as neat agents. The impact of the receptor solution composition was evaluated by comparing the penetration using receptor solutions of different ratios of ethanol and water. For diluted OPCs, a high concentration of ethanol in the receptor solution significantly increased the penetration compared to lower concentrations. When OPCs were applied as neat agents, the composition of the receptor solution only affected the penetration for one of four tested compounds. In conclusion, the flow-through diffusion cell was useful for examining the penetration of OPCs through the epidermal membrane. It was also de...Continue Reading

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Citations

May 13, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·U NygrenL Thors
Mar 25, 2021·Cutaneous and Ocular Toxicology·Lina ThorsAnders Bucht
Dec 2, 2021·Journal of Applied Toxicology : JAT·Lina ThorsAnders Bucht

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