PMID: 9171001Nov 1, 1996Paper

In vitro IL-1 beta and TNF-alpha release from THP-1 monocytes in response to metal ions

Dental Materials : Official Publication of the Academy of Dental Materials
J C WatahaZ Sun

Abstract

Previous studies have shown that biomaterials can activate macrophages to produce cytokines and promote an inflammatory response. Although the toxicity of many metal ions has been extensively investigated, little is known about the ability of these ions to alter cytokine release from macrophages. Yet the release of these ions from biomaterials has been well documented. Previous studies indicated that alterations in cytokine release might be expected because metal ions alter protein production in macrophages at sub-toxic concentrations. Thus, the hypothesis of this study was that metal ions can alter the secretion of cytokines from macrophages at sub-toxic concentrations. The release of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) from macrophages was investigated when the macrophages were exposed to metal ions, with or without lipopolysaccharide (LPS), a component of dental plaque. Human THP-1 macrophages were exposed to ions of Ag, Au, Cu, Hg, and Ni for 24 h. In half of the cultures, LPS was added for the last 4 h. The release of IL-1 beta and TNF-alpha into the medium was measured using enzyme-linked immunosorbent assays. ANOVA and Tukey multiple comparison intervals were used to compare the var...Continue Reading

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Citations

Jul 9, 1999·Journal of Biomedical Materials Research·J C WatahaM Ghazi
Aug 22, 2000·Journal of Biomedical Materials Research·J C WatahaA Schedle
Oct 12, 2012·Annals of Biomedical Engineering·S Hamed AlaviArash Kheradvar
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