PMID: 6538340Feb 1, 1984Paper

In vitro immunoglobulin production by peripheral blood mononuclear cells from multiple myeloma patients and patients with benign monoclonal gammopathy. Regulation by cell subsets

Scandinavian Journal of Immunology
D PeestH Deicher

Abstract

Peripheral blood mononuclear cells (PBM) from four patients with IgG myeloma and four patients with benign monoclonal gammopathy (BMG) were stimulated with pokeweed mitogen (PWM), and the in vitro immunoglobulin production over 7 days was measured with an enzyme-linked immunosorbent assay. All myeloma patients were sufficiently treated with cytostatic drugs. Their PBM did not produce monoclonal Ig in vitro, as opposed to PBM from two patients with BMG. Unseparated PBM from myeloma patients produced smaller amounts of polyclonal Ig than unseparated cells from normal donors. However, macrophage-depleted PBM from myeloma patients produced amounts of Ig comparable to those of normal donors when autologous or allogeneic adherent cells were returned in defined numbers. T cells from three of the four myeloma patients could provide help for the Ig production by B cells from healthy donors. These results indicate that functionally normal polyclonal B cells circulate in the blood of myeloma patients. The circulating T-cell population also has no obvious defect. In contrast, blood macrophages seemed to be altered with respect to their regulating function for polyclonal Ig production. The results obtained by using cell populations from pat...Continue Reading

References

Jun 1, 1977·The Journal of Clinical Investigation·T Paglieroni, M R MacKenzie
Jun 1, 1977·The Journal of Experimental Medicine·R S GehaE Schneeberger
Jan 1, 1978·Scandinavian Journal of Immunology·D PetterssonG Holm
Jul 1, 1982·Scandinavian Journal of Haematology·H MellstedtA Ahre

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Citations

Mar 1, 1986·Diagnostic Microbiology and Infectious Disease·S M Lipson
Mar 21, 1998·British Journal of Haematology·M A FrassanitoF Dammacco
Dec 19, 2001·Current Problems in Surgery·A B PeitzmanR N Townsend
Dec 1, 1988·Scandinavian Journal of Immunology·A C BloemR E Ballieux
Jul 20, 2007·Arquivos De Gastroenterologia·Fabio Gonçalves FerreiraArmando De Capua
Jan 5, 1985·British Medical Journal·F Di PadovaC Zanussi
Jan 1, 1987·Acta Medica Scandinavica·A Wangel

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