In vitro impact of human milk oligosaccharides on Enterobacteriaceae growth

Journal of Agricultural and Food Chemistry
Jennifer L HoeflingerMichael J Miller

Abstract

Human milk oligosaccharides (HMOs) function as prebiotics in the infant gut by selecting for specific species of bifidobacteria and bacteroides, but little is known about their potential utilization by Enterobacteriaceae, the relative numbers of which have been linked to the onset of necrotizing enterocolitis in preterm infants. In this study, the in vitro growth of purified HMOs and other related carbohydrates was evaluated using individual strains of Enterobacteriaceae and an Enterobacteriaceae consortia enriched from piglet feces. None of the Enterobacteriaceae strains grew on 2'-fucosyllactose, 6'-sialyllactose, or lacto-N-neotetraose (LNnT); however, several strains were capable of utilizing galactooligosaccharides, maltodextrin, and the mono- and disaccharide components of HMOs for growth. The enriched fecal consortia also did not grow on 2'-fucosyllactose or 6'-sialyllactose, but there was limited growth on LNnT. It was concluded that 2'-fucosyllactose and 6'-sialyllactose supplementation of preterm infant formula should not lead to an increase in Enterobacteriaceae; however, supplementation with LNnT may require further study.

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Citations

Oct 30, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Amir Mohammad ArmanianNima Salehimehr
Sep 12, 2020·Critical Reviews in Food Science and Nutrition·Emmanuel Pérez-EscalanteLuis Guillermo González-Olivares
Mar 17, 2016·Advances in Nutrition·Esther Castanys-MuñozEnrique Vazquez
Sep 27, 2018·Frontiers in Pediatrics·Veronica Ayechu-MuruzabalBelinda Van't Land
Jul 25, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Badriul HegarYvan Vandenplas
Feb 13, 2021·Annual Review of Immunology·Julie Y Zhou, Brian A Cobb
Jun 11, 2021·Frontiers in Immunology·Anaïs RousseauxMarie Bodinier
Nov 16, 2017·ACS Infectious Diseases·Kelly M Craft, Steven D Townsend
Nov 13, 2018·Journal of Agricultural and Food Chemistry·Agustian SuryaMichael J Miller
Dec 8, 2021·Critical Reviews in Food Science and Nutrition·Elif SakaryaNevin Sanlier

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