PMID: 308088Jun 1, 1978Paper

In vitro induction of cytotoxic effector cells with spontaneous killer cell specificity

The Journal of Experimental Medicine
M Jondal, S Targan

Abstract

The present work shows that stimulation of peripheral blood lymphocytes with autologous or allogeneic B-cell lines leads to a strong induction of cytotoxic effector cells with spontaneous killer (SK) cell specificity, apart from the specific response directed against the particular stimulating cell. To demonstrate this we have determined a relative target cell specificity in the SK system, defined by the short-term 51Cr release assay, and established a relative specificity index (RSI). Using this approach we have been able to show that killer cells induced during a 5-day cocultivation period with B-cell lines have a similar PSI to that of unstimulated SK cells. In addition, we have shown that such killer cells can be induced from several different lymphocyte subpopulations and that they, in contrast to SK cells, do not express Fc receptors. The implications of these findings in relation to the nature, mechanism, and biological significance of the SK cell system is discussed.

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Citations

Mar 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu M Zaretskaia, R A Burkhanov
May 1, 1983·The Japanese Journal of Surgery·S MiyazakiH Tsuji
Mar 1, 1988·The Japanese Journal of Surgery·T AkiyoshiH Tsuji
Mar 1, 1981·Cellular Immunology·R C Burton, J M Plate
Jan 1, 1981·Journal of Immunological Methods·E Piccolella, G Lombardi
Nov 25, 1983·Journal of Immunological Methods·Y M ZaretskayaK T Metodiev
Jan 1, 1981·International Journal of Immunopharmacology·A Uchida, M Micksche
Jun 12, 2003·Developmental and Comparative Immunology·Linling ShenNorman W Miller
Jun 1, 1980·The Journal of Clinical Investigation·R PalaciosE Díaz-Jouanen
Sep 1, 1984·Cellular Immunology·I J RimmE L Reinherz
Jan 1, 1981·Leukemia Research·K A FoonR P Gale
Feb 15, 1981·International Journal of Cancer. Journal International Du Cancer·C A BironJ S Pagano
Jan 1, 1980·Scandinavian Journal of Immunology·C CarnaudR Van der Gaag
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·G R ShellamH J Dawkins
May 15, 1981·International Journal of Cancer. Journal International Du Cancer·A B RickinsonM A Epstein
Dec 1, 1983·European Journal of Immunology·M L ToribioM López-Botet
Jan 1, 1980·Annals of the New York Academy of Sciences·S Targan, F Dorey
May 5, 2017·International Reviews of Immunology·Senthilkumar PreethySamuel J K Abraham
Mar 15, 1981·International Journal of Cancer. Journal International Du Cancer·F VánkyE Klein
May 15, 1979·International Journal of Cancer. Journal International Du Cancer·D J MossJ H Pope

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