In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts

Cancer Letters
Kei HashimotoYasushi Uda

Abstract

The effect of vegetable extracts on the activity of the anticarcinogenic phase II marker enzyme, quinone reductase (QR), was investigated by using human Hep G2 cells as the model system. Hep G2 cells were less sensitive than murine Hepa1c1c7 cells to QR-inducible compounds such as tert-butylhydroquinone which have been widely used to examine the QR-inducing activity of the compounds. However, among 45 different vegetable samples, an extract of ashitaba clearly induced QR activity in Hep G2 cells. Ashitaba is therefore considered to have contained certain substances that could induce QR activity, and such induction may play a role in the anticarcinogenic action of vegetables.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J ProchaskaP Talalay
Mar 1, 1992·Journal of Toxicology and Environmental Health·M H SiessM Suschetet
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P TalalayH J Prochaska
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H J ProchaskaP Talalay
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangP Talalay
Jan 1, 1993·Advances in Enzyme Regulation·T PresteraP Talalay
Jan 1, 1994·Nutrition Research Reviews·I T JohnsonS R Musk

❮ Previous
Next ❯

Citations

Jan 22, 2015·Journal of Agricultural and Food Chemistry·Tugba Boyunegmez TumerCarrie Waterman
Jan 24, 2008·Journal of Food Science·M H ChoW Prinyawiwatkul
Jan 26, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Amma G Adomako-BonsuJeffrey R Fry
Jun 19, 2018·Bioscience, Biotechnology, and Biochemistry·Wensi XuYoshimasa Nakamura
Jul 20, 2021·Bioscience, Biotechnology, and Biochemistry·Hongyan WuYoshimasa Nakamura
Nov 28, 2007·Journal of Agricultural and Food Chemistry·Thippeswamy SannaveerappaIngrid Undeland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.