PMID: 6404998Jan 1, 1983Paper

In vitro inhibition of allogeneic CTL generation and interferon gamma production by the cells of a chemically induced fibrosarcoma

Journal of Interferon Research
T L Bowlin, M R Proffitt

Abstract

We have previously shown that a highly tumorigeneic 3-methylcholanthrene transformed clone (MCA-C3H CL 15) of C3H10T1/2 fibroblasts and a normal nontransformed clone (C3H10 1/2 CL 8) from the same parental stock fail to stimulate the generation of syngeneic cytolytic effector cells. In attempting to further dissect and understand the immune response to these cells, we have extended our studies to examine their ability to stimulate the in vitro generation of allogeneic cytolytic effector cells. This model is unique in that studies of immune responses to tumor cells rarely have or utilize appropriate normal cell counterparts. The normal fibroblasts stimulated both the generation of allogeneic cytolytic T lymphocytes (CTL) and the production of immune interferon (IFN-gamma), whereas the tumor fibroblasts did not. The normal fibroblasts were negative for mycoplasma, indicating that these organisms did not account for the observed IFN-gamma induction. When added as third-party cells to cultures containing allogeneic responders and normal fibroblast stimulators, the tumor fibroblasts inhibited the generation of CTL as well as the production of IFN-gamma. The absence of IFN-gamma was not the result of the tumor fibroblasts absorbing o...Continue Reading

References

Jan 1, 1977·Advances in Cancer Research·I Kamo, H Friedman
Jun 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·P JamesonS E Grossberg
Jan 1, 1979·Annals of the New York Academy of Sciences·G Sonnenfeld, T C Merigan
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GresserE De Maeyer
Apr 1, 1979·Cellular Immunology·A SenikH Wigzell
Dec 15, 1977·Nature·G TrinchieriB B Knowles
Jan 1, 1975·Advances in Cancer Research·O Stutman
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·O J PlesciaK Grinwich
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P LindahlM Tovey
Dec 1, 1970·Virology·W P RoweJ W Hartley
Jun 1, 1969·The Journal of Experimental Medicine·M S SimberkoffL Thomas
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P LindahlI Gresser
Jan 1, 1974·Advances in Cancer Research·R B Herberman
Jan 1, 1972·Advances in Cancer Research·I Gresser
Jan 1, 1970·Annual Review of Microbiology·A L NotkinsR J Howard
Jul 15, 1980·Cellular Immunology·L C OsborneH M Johnson
Jan 1, 1980·Journal of Virological Methods·L HsuM R Proffitt
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·A M Fulton, J G Levy
Mar 1, 1981·Cellular Immunology·R C Burton, J M Plate
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN

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Citations

Oct 14, 1987·Biochemical and Biophysical Research Communications·P S SunkaraA Sjoerdsma

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